PMID- 21809121
OWN - NLM
STAT- MEDLINE
DCOM- 20120316
LR  - 20231213
IS  - 1573-3017 (Electronic)
IS  - 0963-9292 (Linking)
VI  - 20
IP  - 8
DP  - 2011 Nov
TI  - Thyroid disruption effects of environmental level perfluorooctane sulfonates 
      (PFOS) in Xenopus laevis.
PG  - 2069-78
LID - 10.1007/s10646-011-0749-3 [doi]
AB  - Perfluorooctane sulfonate (PFOS), one of the emerging persistent organic 
      pollutants (POPs), has caused growing international concern especially related to 
      the potential disruption in the development and function of thyroid system. 
      Xenopus laevis is an amphibian species widely used as a suitable amphibian model 
      for thyroid disruption research. To study the thyroid disruption effects related 
      to PFOS exposure at environmental low levels, X. laevis tadpoles were exposed to 
      0.1, 1, 10 and 100 mug/l PFOS in water respectively from stage 46/47 to stage 62. 
      The results showed that the time to metamorphosis (presented by forelimb 
      emergence, FLE) did not significantly change with PFOS exposure, but exhibited an 
      increasing trend (except for 10 mug/l exposure). Partial colloid depletion was 
      observed for PFOS exposure, but no significant histological abnormality was 
      observed in treatment groups. In addition, PFOS exposure resulted in 
      up-regulation of thyroid hormone-regulated genes-thyroid receptor beta A (TRbetaA), 
      basic transcription element-binding protein (BTEB) and type II deiodinase (DI2) 
      mRNA expression, presented as an inverted U-shaped dose response pattern. 
      However, the mRNA expression of type III deiodinase (DI3) remained unaffected 
      compared with the control. These results demonstrated that PFOS might disrupt the 
      thyroid system in X. laevis tadpoles regarding FLE changes and regulation 
      alternation of thyroid hormone-regulated genes. Our study has raised new concerns 
      for possible thyroid disruption of PFOS in amphibians at environmental relevant 
      levels.
FAU - Cheng, Yan
AU  - Cheng Y
AD  - Research Center for Import-Export Chemicals Safety of General Administration of 
      Quality Supervision, Inspection and Quarantine of People's Republic of China, 
      Chinese Academy of Inspection and Quarantine, Chaoyang District, Beijing, 100123, 
      China.
FAU - Cui, Yuan
AU  - Cui Y
FAU - Chen, Hui-ming
AU  - Chen HM
FAU - Xie, Wen-ping
AU  - Xie WP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110802
PL  - United States
TA  - Ecotoxicology
JT  - Ecotoxicology (London, England)
JID - 9885956
RN  - 0 (Alkanesulfonic Acids)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Endocrine Disruptors)
RN  - 0 (Fluorocarbons)
RN  - 0 (KLF9 protein, Xenopus)
RN  - 0 (Thyroid Hormone Receptors beta)
RN  - 0 (Transcription Factors)
RN  - 0 (Xenopus Proteins)
RN  - 9H2MAI21CL (perfluorooctane sulfonic acid)
RN  - EC 1.11.1.- (iodothyronine deiodinase type III)
RN  - EC 1.11.1.8 (Iodide Peroxidase)
SB  - IM
MH  - Alkanesulfonic Acids/*toxicity
MH  - Animals
MH  - Brain/drug effects
MH  - DNA-Binding Proteins/genetics
MH  - Dose-Response Relationship, Drug
MH  - Endocrine Disruptors/*toxicity
MH  - *Environmental Exposure
MH  - Female
MH  - Fluorocarbons/*toxicity
MH  - Gene Expression Regulation/drug effects
MH  - Iodide Peroxidase/genetics
MH  - Larva/drug effects
MH  - Male
MH  - Metamorphosis, Biological/*drug effects
MH  - Tail/drug effects
MH  - Thyroid Gland/*drug effects/pathology
MH  - Thyroid Hormone Receptors beta/genetics
MH  - Transcription Factors/genetics
MH  - Xenopus Proteins/genetics
MH  - Xenopus laevis/*physiology
MH  - Iodothyronine Deiodinase Type II
EDAT- 2011/08/03 06:00
MHDA- 2012/03/17 06:00
CRDT- 2011/08/03 06:00
PHST- 2011/07/13 00:00 [accepted]
PHST- 2011/08/03 06:00 [entrez]
PHST- 2011/08/03 06:00 [pubmed]
PHST- 2012/03/17 06:00 [medline]
AID - 10.1007/s10646-011-0749-3 [doi]
PST - ppublish
SO  - Ecotoxicology. 2011 Nov;20(8):2069-78. doi: 10.1007/s10646-011-0749-3. Epub 2011 
      Aug 2.