PMID- 21810022
OWN - NLM
STAT- MEDLINE
DCOM- 20120315
LR  - 20160511
IS  - 1945-0257 (Electronic)
IS  - 1945-0257 (Linking)
VI  - 15
IP  - 11
DP  - 2011 Nov
TI  - MicroRNA 146a expression in rheumatoid arthritis: association with tumor necrosis 
      factor-alpha and disease activity.
PG  - 807-12
LID - 10.1089/gtmb.2011.0026 [doi]
AB  - AIM: MicroRNAs (miRNAs) regulate the expression of many genes and may be involved 
      in regulating the immune response. Expression of microRNA 146a (miRNA 146a) in 
      peripheral blood mononuclear cells was studied by real-time polymerase chain 
      reaction in 70 patients with rheumatoid arthritis (RA), 45 patients with knee 
      osteoarthritis (OA), and 60 healthy controls. Disease activity of RA was assessed 
      using disease activity score (DAS) 28 and physical disability using the Improved 
      Health Assessment Questionnaire. RESULTS: miRNA 146a expression was significantly 
      higher in patients with RA than in those with OA and in controls (p<0.0001) but 
      did not differ between the latter two groups (p=0.06). Tumor necrosis 
      factor-alpha (TNF-alpha) was significantly higher in RA than in OA and controls 
      (p<0.0001) and in OA than controls (p=0.001). In patients with RA, miRNA 146a 
      positively correlated with TNF-alpha (p=0.0003), erythrocyte sedimentation rate (ESR) 
      (p=0.022), and DAS 28 (p=0.009). miRNA 146a expression did not differ between 
      patients with RA receiving anti TNF-alpha and those receiving conventional therapy 
      (p>0.05). CONCLUSION: miRNA 146a expression is upregulated in patients with RA 
      and may be a potentially useful marker of disease activity in these patients. 
      Lack of overexpression of miRNA 146a in the presence of increased TNF-alpha in OA 
      requires further investigation.
FAU - Abou-Zeid, Abla
AU  - Abou-Zeid A
AD  - Department of Clinical Pathology, Faculty of Medicine, Alexandria University, 
      Alexandria, Egypt. aabouzeid4@yahoo.co.uk
FAU - Saad, Mowaffak
AU  - Saad M
FAU - Soliman, Eiman
AU  - Soliman E
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
DEP - 20110802
PL  - United States
TA  - Genet Test Mol Biomarkers
JT  - Genetic testing and molecular biomarkers
JID - 101494210
RN  - 0 (Biomarkers)
RN  - 0 (MIRN146 microRNA, human)
RN  - 0 (MicroRNAs)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
CIN - Genet Test Mol Biomarkers. 2013 Feb;17(2):91-2. PMID: 23193967
MH  - Adolescent
MH  - Adult
MH  - Arthritis, Rheumatoid/*metabolism/pathology
MH  - Biomarkers/metabolism
MH  - Female
MH  - *Gene Expression Regulation
MH  - Humans
MH  - Male
MH  - MicroRNAs/*biosynthesis
MH  - Middle Aged
MH  - Osteoarthritis, Knee/metabolism/pathology
MH  - Tumor Necrosis Factor-alpha/*biosynthesis
EDAT- 2011/08/04 06:00
MHDA- 2012/03/16 06:00
CRDT- 2011/08/04 06:00
PHST- 2011/08/04 06:00 [entrez]
PHST- 2011/08/04 06:00 [pubmed]
PHST- 2012/03/16 06:00 [medline]
AID - 10.1089/gtmb.2011.0026 [doi]
PST - ppublish
SO  - Genet Test Mol Biomarkers. 2011 Nov;15(11):807-12. doi: 10.1089/gtmb.2011.0026. 
      Epub 2011 Aug 2.