PMID- 21810401
OWN - NLM
STAT- MEDLINE
DCOM- 20120920
LR  - 20120214
IS  - 1523-6536 (Electronic)
IS  - 1083-8791 (Linking)
VI  - 18
IP  - 3
DP  - 2012 Mar
TI  - Different risk factors related to adenovirus- or BK virus-associated hemorrhagic 
      cystitis following allogeneic stem cell transplantation.
PG  - 458-65
LID - 10.1016/j.bbmt.2011.07.025 [doi]
AB  - Virus-associated hemorrhagic cystitis (HC) is a major cause of morbidity and 
      mortality following allogeneic hematopoietic stem cell transplantation (HSCT). 
      Although numerous studies have attempted to identify factors that predispose 
      patients to viral HC, its causes remain controversial. We analyzed 
      retrospectively the results of 266 allogeneic HSCTs to identify factors 
      associated with HC. Of this group, 42 patients (15.8%) were diagnosed with viral 
      HC, because of either adenovirus (ADV; n = 26; 9.8%) or BK virus (BKV; n = 16; 
      6.0%). ADV-HC was frequently associated with T cell purging, and was less common 
      in patients with acute graft-versus-host-disease (GVHD). Conversely, BKV-HC was 
      more frequently observed in patients with excessive immune reactions such as 
      GVHD, preengraftment immune reaction, and hemophagocytic syndrome. These 
      observations indicate that ADV- and BKV-HC may differ significantly in their risk 
      factors and pathogenesis. Profound immune deficiency is more likely to be 
      associated with ADV-HC, whereas immune hyperactivity might play a key role in 
      BKV-HC.
CI  - Copyright A(c) 2012 American Society for Blood and Marrow Transplantation. 
      Published by Elsevier Inc. All rights reserved.
FAU - Mori, Yasuo
AU  - Mori Y
AD  - Department of Medicine and Biosystemic Science, Graduate School of Medical 
      Sciences, Kyushu University, Fukuoka, Japan.
FAU - Miyamoto, Toshihiro
AU  - Miyamoto T
FAU - Kato, Koji
AU  - Kato K
FAU - Kamezaki, Kenjiro
AU  - Kamezaki K
FAU - Kuriyama, Takuro
AU  - Kuriyama T
FAU - Oku, Seido
AU  - Oku S
FAU - Takenaka, Katsuto
AU  - Takenaka K
FAU - Iwasaki, Hiromi
AU  - Iwasaki H
FAU - Harada, Naoki
AU  - Harada N
FAU - Shiratsuchi, Motoaki
AU  - Shiratsuchi M
FAU - Abe, Yasunobu
AU  - Abe Y
FAU - Nagafuji, Koji
AU  - Nagafuji K
FAU - Teshima, Takanori
AU  - Teshima T
FAU - Akashi, Koichi
AU  - Akashi K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110731
PL  - United States
TA  - Biol Blood Marrow Transplant
JT  - Biology of blood and marrow transplantation : journal of the American Society for 
      Blood and Marrow Transplantation
JID - 9600628
SB  - IM
MH  - Adenoviridae/isolation & purification
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - BK Virus/isolation & purification
MH  - Cystitis/*etiology/virology
MH  - Cytomegalovirus Infections/*etiology/pathology
MH  - Female
MH  - Hematopoietic Stem Cell Transplantation/*adverse effects/methods
MH  - Hemorrhage/*etiology/virology
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Middle Aged
MH  - Polyomavirus Infections/*etiology/pathology
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Transplantation, Homologous
MH  - Tumor Virus Infections/*etiology/pathology
MH  - Young Adult
EDAT- 2011/08/04 06:00
MHDA- 2012/09/21 06:00
CRDT- 2011/08/04 06:00
PHST- 2011/06/04 00:00 [received]
PHST- 2011/07/27 00:00 [accepted]
PHST- 2011/08/04 06:00 [entrez]
PHST- 2011/08/04 06:00 [pubmed]
PHST- 2012/09/21 06:00 [medline]
AID - S1083-8791(11)00325-9 [pii]
AID - 10.1016/j.bbmt.2011.07.025 [doi]
PST - ppublish
SO  - Biol Blood Marrow Transplant. 2012 Mar;18(3):458-65. doi: 
      10.1016/j.bbmt.2011.07.025. Epub 2011 Jul 31.