PMID- 21810896
OWN - NLM
STAT- MEDLINE
DCOM- 20120627
LR  - 20120305
IS  - 1752-8976 (Electronic)
IS  - 1470-3203 (Linking)
VI  - 13
IP  - 1
DP  - 2012 Mar
TI  - Association between genetic polymorphism of the angiotensin-converting enzyme and 
      diabetic nephropathy: a meta-analysis comprising 26,580 subjects.
PG  - 161-74
LID - 10.1177/1470320311417655 [doi]
AB  - INTRODUCTION: The effect of angiotensin-converting enzyme (ACE) 
      insertion/deletion (I/D) polymorphism on risk of diabetic nephropathy (DN) is 
      still conflicting. The present meta-analysis was performed to evaluate the 
      overall risk of this polymorphism associated with DN in different groups. 
      MATERIALS AND METHODS: A predefined search was performed on 14,108 DN cases and 
      12,472 controls from 63 published studies by searching electronic databases and 
      reference lists of relevant articles. RESULTS: In this meta-analysis, we found a 
      significant association between the ACE I/D polymorphism and the risk of DN for 
      all genetic models (ID versus II: odds ratio [OR] = 1.12, 95% confidence interval 
      [CI] 1.02-1.24; DD versus II: OR = 1.27, 95% CI 1.13-1.44; allele contrast: OR = 
      1.15, 95% CI 1.08-1.23; dominant model: OR = 1.18, 95% CI 1.07-1.31; and 
      recessive model: OR = 1.18, 95% CI 1.08-1.30, respectively). In stratified 
      analysis by ethnicity and DM type, we further found that the Asian group with 
      type 2 diabetes mellitus (T2DM) showed a significant association for all genetic 
      models (ID versus II: OR = 1.25, 95% CI 1.07-1.47; DD versus II: OR = 1.57, 95% 
      CI 1.24-1.98; allele contrast: OR = 1.30, 95% CI 1.15-1.46; dominant model: OR = 
      1.37, 95% CI 1.10-1.69; and recessive model: OR = 1.34, 95% CI 1.15-1.56, 
      respectively). CONCLUSIONS: Our study suggested that the ACE I/D polymorphism may 
      contribute to DN development, especially in the Asian group with T2DM.
FAU - Wang, Furu
AU  - Wang F
AD  - JiangSu Provincial Center for Disease Prevention and Control, Nanjing, China. 
      wangfuru1983@126.com
FAU - Fang, Qiaoqiao
AU  - Fang Q
FAU - Yu, Ningle
AU  - Yu N
FAU - Zhao, Deyu
AU  - Zhao D
FAU - Zhang, Yimei
AU  - Zhang Y
FAU - Wang, Jin
AU  - Wang J
FAU - Wang, Quan
AU  - Wang Q
FAU - Zhou, Xianfeng
AU  - Zhou X
FAU - Cao, Xingjiang
AU  - Cao X
FAU - Fan, Xiangyong
AU  - Fan X
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20110802
PL  - England
TA  - J Renin Angiotensin Aldosterone Syst
JT  - Journal of the renin-angiotensin-aldosterone system : JRAAS
JID - 100971636
RN  - EC 3.4.15.1 (ACE protein, human)
RN  - EC 3.4.15.1 (Peptidyl-Dipeptidase A)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Diabetic Nephropathies/*enzymology/*genetics
MH  - *Genetic Association Studies
MH  - Genetic Heterogeneity
MH  - *Genetic Predisposition to Disease
MH  - Humans
MH  - INDEL Mutation/genetics
MH  - Middle Aged
MH  - Models, Genetic
MH  - Odds Ratio
MH  - Peptidyl-Dipeptidase A/*genetics
MH  - *Polymorphism, Genetic
MH  - Publication Bias
EDAT- 2011/08/04 06:00
MHDA- 2012/06/28 06:00
CRDT- 2011/08/04 06:00
PHST- 2011/08/04 06:00 [entrez]
PHST- 2011/08/04 06:00 [pubmed]
PHST- 2012/06/28 06:00 [medline]
AID - 1470320311417655 [pii]
AID - 10.1177/1470320311417655 [doi]
PST - ppublish
SO  - J Renin Angiotensin Aldosterone Syst. 2012 Mar;13(1):161-74. doi: 
      10.1177/1470320311417655. Epub 2011 Aug 2.