PMID- 2181170
OWN - NLM
STAT- MEDLINE
DCOM- 19900510
LR  - 20071115
IS  - 0368-2811 (Print)
IS  - 0368-2811 (Linking)
VI  - 20
IP  - 1
DP  - 1990 Mar
TI  - Adjuvant chemotherapy for gastric cancer in Japan: present status and suggestions 
      for rational clinical trials.
PG  - 30-42
AB  - A review of the present status of adjuvant chemotherapy for gastric cancer in 
      Japan has been made. The single use of mitomycin C (MMC) after curative 
      gastrectomy, a multidrug combination of MMC, 5-fluorouracil (5FU) and cytosine 
      arabinoside (CA) (MFC therapy), and a combination of inductive MFC followed by 
      maintenance 5FU in an adjuvant setting have proved beneficial in subsets of 
      moderately locally advanced diseases. The advantages of the Japanese trials seem 
      to be attributable to perioperative chemotherapy with MMC and/or 5FU, obviously 
      given in less amounts than in other countries, against minimum residual tumors 
      following surgery. Effort should be directed, however, to improving the quality 
      of data, at present biased by a number of exclusions and drop-outs which should 
      not be considered negligible. The author mentions the beneficial use of a 
      computer-assisted randomization system for avoiding the violation of entry 
      criteria, and of controlling data quality with individual dose intensity (I.D.I.) 
      and relative performance (R.P.) indices. Prerequisites for success in the 
      adjuvant chemotherapy's clinical trial included planning effective regimens, 
      proper selection of subjects and faithful performance of proposed regimens.
FAU - Nakajima, T
AU  - Nakajima T
AD  - Division of Gastrointestinal Surgery, Cancer Institute Hospital, Tokyo.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Review
PL  - England
TA  - Jpn J Clin Oncol
JT  - Japanese journal of clinical oncology
JID - 0313225
SB  - IM
MH  - Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
MH  - Clinical Trials as Topic
MH  - Combined Modality Therapy
MH  - Gastrectomy
MH  - Humans
MH  - Japan
MH  - Stomach Neoplasms/*drug therapy/surgery
RF  - 66
EDAT- 1990/03/01 00:00
MHDA- 1990/03/01 00:01
CRDT- 1990/03/01 00:00
PHST- 1990/03/01 00:00 [pubmed]
PHST- 1990/03/01 00:01 [medline]
PHST- 1990/03/01 00:00 [entrez]
PST - ppublish
SO  - Jpn J Clin Oncol. 1990 Mar;20(1):30-42.