PMID- 21811983
OWN - NLM
STAT- MEDLINE
DCOM- 20111012
LR  - 20221207
IS  - 1003-9406 (Print)
IS  - 1003-9406 (Linking)
VI  - 28
IP  - 4
DP  - 2011 Aug
TI  - [Recombination between human leukocyte antigen -A and -C loci within two Chinese 
      Han families].
PG  - 417-20
LID - 10.3760/cma.j.issn.1003-9406.2011.04.013 [doi]
AB  - OBJECTIVE: To investigate the recombination events between human leukocyte 
      antigen (HLA) loci within two families. METHODS: Identification of HLA-A, -C, -B, 
      -DRB1 and -DQB1 loci was firstly carried out using polymerase chain 
      reaction-sequence specific oligonucleotide. Then HLA high resolution typing was 
      performed using polymerase chain reaction sequencing-based typing. The 
      recombination between HLA loci was identified by family genetic analysis. The 
      parentage possibility was analyzed by short tandom repeat technique. RESULTS: 
      Recombination between the HLA-A and C loci was identified within two families. 
      One individual inherited a paternal haplotype that was the result of a 
      recombination event between the father's HLA-A and -C loci on his chromosomes. 
      The other individual inherited a maternal haplotype that was the result of a 
      recombination event between the mother's HLA-A and -C loci. The high parentage 
      possibilities were obtained in the family members. CONCLUSION: The recombination 
      events of HLA-A and -C have been found in two Chinese families, which may help 
      further study on the mechanism of HLA recombination.
FAU - Wang, Wei
AU  - Wang W
AD  - Blood Center of Zhejiang Province, Key Laboratory of Blood Safety Research of 
      Ministry of Health, Hangzhou, Zhejiang 310006, P. R. China.
FAU - Han, Zhe-dong
AU  - Han ZD
FAU - Chen, Nan-ying
AU  - Chen NY
FAU - He, Jun-jun
AU  - He JJ
FAU - Zhang, Wei
AU  - Zhang W
FAU - Zhu, Fa-ming
AU  - Zhu FM
FAU - Lv, Hang-jun
AU  - Lv HJ
FAU - Yan, Li-xing
AU  - Yan LX
LA  - chi
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi
JT  - Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese 
      journal of medical genetics
JID - 9425197
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-C Antigens)
SB  - IM
MH  - Asian People/ethnology/*genetics
MH  - China/ethnology
MH  - Ethnicity/*genetics
MH  - Female
MH  - Genetic Loci/*genetics
MH  - HLA-A Antigens/*genetics
MH  - HLA-C Antigens/*genetics
MH  - Haplotypes/genetics
MH  - Humans
MH  - Male
MH  - *Pedigree
MH  - Recombination, Genetic/*genetics
EDAT- 2011/08/04 06:00
MHDA- 2011/10/13 06:00
CRDT- 2011/08/04 06:00
PHST- 2011/08/04 06:00 [entrez]
PHST- 2011/08/04 06:00 [pubmed]
PHST- 2011/10/13 06:00 [medline]
AID - 940628084 [pii]
AID - 10.3760/cma.j.issn.1003-9406.2011.04.013 [doi]
PST - ppublish
SO  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2011 Aug;28(4):417-20. doi: 
      10.3760/cma.j.issn.1003-9406.2011.04.013.