PMID- 21812052
OWN - NLM
STAT- MEDLINE
DCOM- 20120126
LR  - 20120326
IS  - 1099-1352 (Electronic)
IS  - 0952-3499 (Linking)
VI  - 24
IP  - 5
DP  - 2011 Sep-Oct
TI  - Simultaneous topography and recognition imaging on endothelial cells.
PG  - 788-94
LID - 10.1002/jmr.1126 [doi]
AB  - Determining the landscape of specific binding sites on biological samples with 
      high spatial accuracy (in the order of several nanometres) is an important task 
      in many fields of biological science. During the past five years, dynamic 
      recognition imaging (e.g. simultaneous topography and recognition (TREC) imaging) 
      has proven to be a powerful technique in biophysical research. This technique 
      becomes an indispensable tool for high-resolution receptor mapping as it has been 
      successfully demonstrated on different biomolecular model systems. In these 
      studies, the topographical imaging of receptor molecules is combined with 
      molecular recognition by their cognate ligands bound to the atomic force 
      microscope (AFM) tip via a flexible and distensible tether. In this review, we 
      describe the principles of TREC imaging and provide a flavour of its recent 
      application on endothelial cells.
CI  - Copyright (c) 2011 John Wiley & Sons, Ltd.
FAU - Chtcheglova, L A
AU  - Chtcheglova LA
AD  - Center for Advanced Bioanalysis (CBL), Scharitzerstrasse 6-8, A-4020 Linz, 
      Austria. lilia.chtcheglova@cbl.at
FAU - Hinterdorfer, P
AU  - Hinterdorfer P
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - J Mol Recognit
JT  - Journal of molecular recognition : JMR
JID - 9004580
RN  - 0 (Actins)
RN  - 0 (Cadherins)
SB  - IM
MH  - Actins/metabolism
MH  - Animals
MH  - Cadherins/metabolism
MH  - Endothelial Cells/*cytology/*metabolism
MH  - Mice
MH  - Microscopy, Atomic Force/methods
EDAT- 2011/08/04 06:00
MHDA- 2012/01/27 06:00
CRDT- 2011/08/04 06:00
PHST- 2011/08/04 06:00 [entrez]
PHST- 2011/08/04 06:00 [pubmed]
PHST- 2012/01/27 06:00 [medline]
AID - 10.1002/jmr.1126 [doi]
PST - ppublish
SO  - J Mol Recognit. 2011 Sep-Oct;24(5):788-94. doi: 10.1002/jmr.1126.