PMID- 21812765
OWN - NLM
STAT- MEDLINE
DCOM- 20120529
LR  - 20111012
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Linking)
VI  - 78
IP  - 5
DP  - 2011 Nov
TI  - Weak or absent evidence for the association of HLA-DR antigens with risk of 
      thyroid carcinoma: a meta-analysis of observational studies.
PG  - 382-9
LID - 10.1111/j.1399-0039.2011.01754.x [doi]
AB  - Inconsistent reports of associations between human leukocyte antigen (HLA)-DR and 
      thyroid cancers exist. We conducted a comprehensive search of the PubMed, Scopus 
      and Web of Science databases. Using random-effects modeling, subgroup analyses, 
      meta-regression and prediction interval (PI) estimation, we combined the existing 
      evidence from 13 studies (977 cases of thyroid cancer and 3735 controls). Only 
      HLA-DR1 and HLA-DR11 were significantly associated; however, the evidence for 
      HLA-DR11 came from only three studies while that for HLA-DR1 had large 
      between-study heterogeneity. All the PIs estimated in the study straddled unity. 
      Therefore, current evidence for the studied association is incomplete as well as 
      uncertain. Attempts to include HLA-DR typing as a prognostic or therapeutic 
      marker may be premature at this time.
CI  - (c) 2011 John Wiley & Sons A/S.
FAU - Kamdi, A S
AU  - Kamdi AS
AD  - Center for the Study of Community Health, University of Alabama at Birmingham, 
      Birmingham, AL, USA.
FAU - Kandavalli, N B
AU  - Kandavalli NB
FAU - Emusu, D
AU  - Emusu D
FAU - Jain, N
AU  - Jain N
FAU - Mamtani, M
AU  - Mamtani M
FAU - Porterfield, J R Jr
AU  - Porterfield JR Jr
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20110804
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DR Serological Subtypes)
RN  - 0 (HLA-DR1 Antigen)
RN  - 0 (HLA-DR11 antigen)
SB  - IM
MH  - Adult
MH  - Case-Control Studies
MH  - Female
MH  - HLA-DR Antigens/*genetics/immunology
MH  - HLA-DR Serological Subtypes/genetics/immunology
MH  - HLA-DR1 Antigen/genetics/immunology
MH  - Humans
MH  - Male
MH  - Thyroid Neoplasms/epidemiology/*genetics/*immunology
EDAT- 2011/08/05 06:00
MHDA- 2012/05/30 06:00
CRDT- 2011/08/05 06:00
PHST- 2011/08/05 06:00 [entrez]
PHST- 2011/08/05 06:00 [pubmed]
PHST- 2012/05/30 06:00 [medline]
AID - 10.1111/j.1399-0039.2011.01754.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2011 Nov;78(5):382-9. doi: 10.1111/j.1399-0039.2011.01754.x. 
      Epub 2011 Aug 4.