PMID- 21812766
OWN - NLM
STAT- MEDLINE
DCOM- 20120529
LR  - 20221207
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Linking)
VI  - 78
IP  - 5
DP  - 2011 Nov
TI  - Assessment of the influence of HLA class I and class II loci on the prevalence of 
      keloid disease in Jamaican Afro-Caribbeans.
PG  - 390-6
LID - 10.1111/j.1399-0039.2011.01755.x [doi]
AB  - Keloid disease (KD) is a common abnormal cutaneous fibrotic disorder of unknown 
      aetiopathogenesis. KD is reported to have a strong genetic component as it is 
      often familial and has a high incidence in certain ethnicities, in particular 
      those of Afro-Caribbean origin. Genetic risk factors combined with aberrant 
      lesional inflammatory responses point to the human leukocyte antigen (HLA) system 
      as a viable target for investigating disease aetiology. Sequence specific primer 
      polymerase chain reaction with allele sequencing was used to determine HLA-DQA1 
      and DQB1 allele frequencies (AF) for 165 KD patients and 119 healthy controls of 
      black Jamaican Afro-Caribbean origin. HLA class I alleles A*01, A*03, A*25, B*07 
      and Cw*08:02, previously identified as KD associated in a different ethnicity, 
      were also analysed. Allele sequencing confirmed typing accuracy but no 
      statistically significant differences in AF were identified between KD patients 
      and controls. Furthermore, KD subgroups including patient gender, family history 
      and multiple- or single-site scarring did not show significant allele-disease 
      associations.
CI  - (c) 2011 John Wiley & Sons A/S.
FAU - Ashcroft, K J
AU  - Ashcroft KJ
AD  - Plastic & Reconstructive Surgery Research, Manchester Interdisciplinary 
      Biocentre, University of Manchester, Manchester, UK.
FAU - Syed, F
AU  - Syed F
FAU - Arscott, G
AU  - Arscott G
FAU - Bayat, A
AU  - Bayat A
LA  - eng
GR  - Department of Health/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110804
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA-D Antigens)
RN  - 0 (HLA-DQ alpha-Chains)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQA1 antigen)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - *Black People
MH  - Ethnicity/*genetics
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - HLA-D Antigens/*genetics
MH  - HLA-DQ alpha-Chains/genetics
MH  - HLA-DQ beta-Chains/genetics
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Humans
MH  - Keloid/ethnology/*genetics/immunology
MH  - Male
MH  - Prevalence
MH  - Skin Diseases, Metabolic/ethnology/*genetics/immunology
MH  - Young Adult
EDAT- 2011/08/05 06:00
MHDA- 2012/05/30 06:00
CRDT- 2011/08/05 06:00
PHST- 2011/08/05 06:00 [entrez]
PHST- 2011/08/05 06:00 [pubmed]
PHST- 2012/05/30 06:00 [medline]
AID - 10.1111/j.1399-0039.2011.01755.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2011 Nov;78(5):390-6. doi: 10.1111/j.1399-0039.2011.01755.x. 
      Epub 2011 Aug 4.