PMID- 21813038
OWN - NLM
STAT- MEDLINE
DCOM- 20120228
LR  - 20191210
IS  - 1741-203X (Electronic)
IS  - 1041-6102 (Linking)
VI  - 23
IP  - 10
DP  - 2011 Dec
TI  - Perseverative errors on the Wisconsin Card Sorting Test and brain perfusion 
      imaging in mild Alzheimer's disease.
PG  - 1552-9
LID - 10.1017/S1041610211001463 [doi]
AB  - BACKGROUND: The Wisconsin Card Sorting Test (WCST) has long been used to 
      investigate deficits in executive function in humans. The majority of studies 
      investigating deficient WCST performance focused on the number of categories 
      achieved (CA) and the number of perseverative errors of the Nelson type (PEN). 
      However, there is insufficient evidence that these two measures reflect the same 
      neural deficits. METHODS: Twenty AD patients with high PEN scores, and 20 age- 
      and sex-matched AD patients with low PEN scores were selected. All 40 subjects 
      underwent brain SPECT, and the SPECT images were analyzed by Statistical 
      Parametric Mapping. RESULTS: No significant differences were found between high 
      and low PEN score groups with respect to years of education, Addenbrooke's 
      Cognitive Examination scores, and Mini-Mental State Examination scores. However, 
      higher z scores for hypoperfusion in the bilateral rectal and orbital gyri were 
      observed in the high PEN score group compared with the low PEN score group. 
      CONCLUSIONS: Our results suggest that functional activity of the bilateral rectal 
      and orbital gyri is closely related to PEN scores on a modified WCST (mWCST). The 
      PEN score on a mWCST might be a promising index of dysfunction of the 
      orbitofrontal area among patients with mild AD.
FAU - Terada, Seishi
AU  - Terada S
AD  - Department of Neuropsychiatry, Okayama University Graduate School of Medicine, 
      Dentistry and Pharmaceutical Sciences, Okayama, Japan. terada@cc.okayama-u.ac.jp
FAU - Sato, Shuhei
AU  - Sato S
FAU - Honda, Hajime
AU  - Honda H
FAU - Kishimoto, Yuki
AU  - Kishimoto Y
FAU - Takeda, Naoya
AU  - Takeda N
FAU - Oshima, Etsuko
AU  - Oshima E
FAU - Yokota, Osamu
AU  - Yokota O
FAU - Uchitomi, Yosuke
AU  - Uchitomi Y
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110804
PL  - England
TA  - Int Psychogeriatr
JT  - International psychogeriatrics
JID - 9007918
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Alzheimer Disease/*diagnostic imaging/*psychology
MH  - Brain/*diagnostic imaging
MH  - Case-Control Studies
MH  - Cerebrovascular Circulation
MH  - *Executive Function
MH  - Female
MH  - Humans
MH  - Male
MH  - Neuropsychological Tests/*standards
MH  - Severity of Illness Index
MH  - *Tomography, Emission-Computed, Single-Photon
EDAT- 2011/08/05 06:00
MHDA- 2012/03/01 06:00
CRDT- 2011/08/05 06:00
PHST- 2011/08/05 06:00 [entrez]
PHST- 2011/08/05 06:00 [pubmed]
PHST- 2012/03/01 06:00 [medline]
AID - S1041610211001463 [pii]
AID - 10.1017/S1041610211001463 [doi]
PST - ppublish
SO  - Int Psychogeriatr. 2011 Dec;23(10):1552-9. doi: 10.1017/S1041610211001463. Epub 
      2011 Aug 4.