PMID- 21813208
OWN - NLM
STAT- MEDLINE
DCOM- 20120716
LR  - 20151119
IS  - 1527-3296 (Electronic)
IS  - 0196-6553 (Linking)
VI  - 40
IP  - 3
DP  - 2012 Apr
TI  - Overview of adverse events related to invasive procedures in the intensive care 
      unit.
PG  - 241-6
LID - 10.1016/j.ajic.2011.04.005 [doi]
AB  - BACKGROUND: This study was conducted to determine the frequency, predictors, and 
      clinical impact of adverse events (AEs) related to invasive procedures in the 
      intensive care unit (ICU). METHODS: This was a prospective observational study of 
      ICUs in a university hospital. RESULTS: A total of 893 patients requiring 
      invasive procedures were admitted over a 1-year period. Among these, 310 patients 
      (34.7%) experienced a total of 505 AEs. The mean number of AEs per patient was 
      1.6 +/- 1.1 (range, 1-7). Infectious AEs were significantly more frequent than 
      mechanical AEs (60.4% vs 39.6%; P = .01). Factors independently associated with 
      AE occurrence were isolation of multidrug-resistant bacteria at ICU admission, >5 
      invasive procedures, and ICU length of stay >8 days. Thirty-three AEs (6.5%) 
      resulted in severe clinical impact, including 24 deaths. Ventilator-associated 
      pneumonia (VAP) accounted for 62.5% of the deaths related to AEs. CONCLUSIONS: 
      One-third of critically ill patients experienced AEs related to invasive 
      procedures. Severe AEs were associated with 11% of all ICU deaths. VAP was the 
      most frequent AE related to death. An improved assessment of the risk-benefit 
      balance before each invasive procedure and increased efforts to decrease VAP 
      prevalence are needed to reduce AE-related mortality.
CI  - Copyright (c) 2012 Association for Professionals in Infection Control and 
      Epidemiology, Inc. Published by Mosby, Inc. All rights reserved.
FAU - Pottier, Veronique
AU  - Pottier V
AD  - Department of Anesthesia and Surgical Intensive Care, Caen University Hospital, 
      France. pottier-v@chu-caen.fr
FAU - Daubin, Cedric
AU  - Daubin C
FAU - Lerolle, Nicolas
AU  - Lerolle N
FAU - Gaillard, Cathy
AU  - Gaillard C
FAU - Viquesnel, Gerald
AU  - Viquesnel G
FAU - Plaud, Benoit
AU  - Plaud B
FAU - Hanouz, Jean-Luc
AU  - Hanouz JL
FAU - Charbonneau, Pierre
AU  - Charbonneau P
LA  - eng
PT  - Journal Article
DEP - 20110803
PL  - United States
TA  - Am J Infect Control
JT  - American journal of infection control
JID - 8004854
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Critical Care/*methods
MH  - Female
MH  - Humans
MH  - Iatrogenic Disease/*epidemiology
MH  - Incidence
MH  - Intensive Care Units
MH  - Male
MH  - Middle Aged
MH  - Risk Factors
EDAT- 2011/08/05 06:00
MHDA- 2012/07/17 06:00
CRDT- 2011/08/05 06:00
PHST- 2010/12/02 00:00 [received]
PHST- 2011/04/04 00:00 [revised]
PHST- 2011/04/05 00:00 [accepted]
PHST- 2011/08/05 06:00 [entrez]
PHST- 2011/08/05 06:00 [pubmed]
PHST- 2012/07/17 06:00 [medline]
AID - S0196-6553(11)00326-9 [pii]
AID - 10.1016/j.ajic.2011.04.005 [doi]
PST - ppublish
SO  - Am J Infect Control. 2012 Apr;40(3):241-6. doi: 10.1016/j.ajic.2011.04.005. Epub 
      2011 Aug 3.