PMID- 21813732 OWN - NLM STAT- MEDLINE DCOM- 20111207 LR - 20110804 IS - 1945-1997 (Electronic) IS - 0098-6151 (Linking) VI - 111 IP - 7 Suppl 5 DP - 2011 Jul TI - Assessing cardiovascular risk factors and selecting agents to successfully treat patients with type 2 diabetes mellitus. PG - S2-12 AB - Type 2 diabetes mellitus (T2DM), obesity, and cardiovascular disease (CVD) share a common pathogenic mechanism. The prevalence of each of these conditions is increasing at an alarming rate. Despite the availability of several treatment options for patients with T2DM and the use of intensive regimens combining several antidiabetic drugs, less than half of all patients reach a target glycosylated hemoglobin level of less than 7%. Given the rapid increase in the number of patients with T2DM and obesity, as well as the CVD morbidity and mortality associated with this burden, efforts must be made to change the course of disease. The author reviews clinical trial data on the effect of glucose control on CVD risk, the selection and timing of antihyperglycemic agents, the management of associated CVD risk factors, and strategies to improve patient adherence and acceptance-with the goal of assisting physicians in selecting appropriate management strategies for their patients with T2DM. FAU - Baldwin, Mark D AU - Baldwin MD AD - Dublin Medical Clinic II, 6350 Frantz Rd., Dublin, OH 43017-1382, USA. mdb51@earthlink.net LA - eng PT - Journal Article PT - Review PL - United States TA - J Am Osteopath Assoc JT - The Journal of the American Osteopathic Association JID - 7503065 RN - 0 (Blood Glucose) RN - 0 (Hypoglycemic Agents) SB - IM MH - Blood Glucose/*analysis MH - Cardiovascular Diseases/*epidemiology/prevention & control MH - Comorbidity MH - Diabetes Mellitus, Type 2/diagnosis/*drug therapy/*epidemiology MH - Diabetic Angiopathies/epidemiology/prevention & control MH - Female MH - Humans MH - Hypertension/diagnosis/epidemiology MH - Hypoglycemic Agents/*therapeutic use MH - Incidence MH - Male MH - Obesity/*epidemiology/prevention & control MH - Prognosis MH - Risk Assessment MH - Severity of Illness Index MH - Smoking/adverse effects/epidemiology MH - Survival Analysis EDAT- 2011/08/10 06:00 MHDA- 2011/12/13 00:00 CRDT- 2011/08/05 06:00 PHST- 2011/08/05 06:00 [entrez] PHST- 2011/08/10 06:00 [pubmed] PHST- 2011/12/13 00:00 [medline] AID - 111/7_suppl_5/S2 [pii] PST - ppublish SO - J Am Osteopath Assoc. 2011 Jul;111(7 Suppl 5):S2-12.