PMID- 21815673
OWN - NLM
STAT- MEDLINE
DCOM- 20111221
LR  - 20131121
IS  - 1520-5126 (Electronic)
IS  - 0002-7863 (Linking)
VI  - 133
IP  - 35
DP  - 2011 Sep 7
TI  - Determination of molecular configuration by debye length modulation.
PG  - 13886-9
LID - 10.1021/ja205684a [doi]
AB  - Silicon nanowire field effect transistors (FETs) have emerged as ultrasensitive, 
      label-free biodetectors that operate by sensing bound surface charge. However, 
      the ionic strength of the environment (i.e., the Debye length of the solution) 
      dictates the effective magnitude of the surface charge. Here, we show that 
      control of the Debye length determines the spatial extent of sensed bound surface 
      charge on the sensor. We apply this technique to different methods of antibody 
      immobilization, demonstrating different effective distances of induced charge 
      from the sensor surface.
FAU - Vacic, Aleksandar
AU  - Vacic A
AD  - Departments of Electrical, Yale University, New Haven, Connecticut 06511, United 
      States. aleksandar.vacic@yale.edu
FAU - Criscione, Jason M
AU  - Criscione JM
FAU - Rajan, Nitin K
AU  - Rajan NK
FAU - Stern, Eric
AU  - Stern E
FAU - Fahmy, Tarek M
AU  - Fahmy TM
FAU - Reed, Mark A
AU  - Reed MA
LA  - eng
GR  - R01EB008260/EB/NIBIB NIH HHS/United States
GR  - RR026992/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20110816
PL  - United States
TA  - J Am Chem Soc
JT  - Journal of the American Chemical Society
JID - 7503056
RN  - 0 (Antibodies, Immobilized)
RN  - Z4152N8IUI (Silicon)
SB  - IM
MH  - Antibodies, Immobilized/*chemistry
MH  - Biosensing Techniques/*instrumentation
MH  - Molecular Conformation
MH  - Nanowires/*chemistry
MH  - Osmolar Concentration
MH  - Silicon/*chemistry
MH  - Surface Properties
MH  - *Transistors, Electronic
EDAT- 2011/08/06 06:00
MHDA- 2011/12/22 06:00
CRDT- 2011/08/06 06:00
PHST- 2011/08/06 06:00 [entrez]
PHST- 2011/08/06 06:00 [pubmed]
PHST- 2011/12/22 06:00 [medline]
AID - 10.1021/ja205684a [doi]
PST - ppublish
SO  - J Am Chem Soc. 2011 Sep 7;133(35):13886-9. doi: 10.1021/ja205684a. Epub 2011 Aug 
      16.