PMID- 21815896
OWN - NLM
STAT- MEDLINE
DCOM- 20120824
LR  - 20211020
IS  - 1530-0277 (Electronic)
IS  - 0145-6008 (Print)
IS  - 0145-6008 (Linking)
VI  - 36
IP  - 1
DP  - 2012 Jan
TI  - Auditory brainstem response (ABR) abnormalities across the life span of rats 
      prenatally exposed to alcohol.
PG  - 83-96
LID - 10.1111/j.1530-0277.2011.01594.x [doi]
AB  - BACKGROUND: Fetal alcohol syndrome (FAS) is a leading cause of neurodevelopmental 
      impairments (NDIs) in developed countries. Sensory deficits can play a major role 
      in NDI, yet few studies have investigated the effects of prenatal alcohol 
      exposure on sensory function. In addition, there is a paucity of information on 
      the lifelong effects of prenatal alcohol exposure. Thus, we sought to investigate 
      the effects of prenatal alcohol exposure on auditory function across the life 
      span in an animal model. Based on prior findings with prenatal alcohol exposure 
      and other forms of adverse prenatal environments, we hypothesized that animals 
      prenatally exposed to alcohol would show an age-dependent pattern of (i) hearing 
      and neurological abnormalities as postweanling pups, (ii) a substantial 
      dissipation of such abnormalities in young adulthood, and (iii) a resurgence of 
      such abnormalities in middle-aged adulthood. METHODS: Pregnant rats were randomly 
      assigned to an untreated control (CON), a pair-fed control (PFC), or an 
      alcohol-treated (ALC) group. The ALC dams were gavaged with 6 mg/kg alcohol daily 
      from gestation day (GD) 6 to 21. The PFC dams were gavaged daily from GD6 to GD21 
      with an isocaloric and isovolumetric water-based solution of maltose-dextrins and 
      pair-fed to the ALC dams. The CON dams were the untreated group to which the ALC 
      and CON groups were compared. Hearing and neurological functions in the offspring 
      were assessed with the auditory brainstem response (ABR) at the postnatal ages of 
      22, 220, and 520 days. RESULTS: In accord with our hypothesis, ABR abnormalities 
      were first observed in the postweanling pups, largely dissipated in young 
      adulthood, and then resurged in middle-aged adulthood. This age-related pattern 
      suggests that the ALC pups had a developmental delay that dissipated in young 
      adulthood and an enhanced age-related deterioration that occurred in middle-aged 
      adulthood. Such a pattern is consistent with the fetal programming hypothesis of 
      adult-onset diseases (the Barker hypothesis). CONCLUSIONS: Our findings have 
      important clinical implications for the assessment and management of (i) 
      childhood hearing disorders and their comorbidities (i.e., speech-and-language, 
      learning, and attention deficit disorders) and (ii) enhanced age-related hearing 
      and neurological degeneration in middle-aged adulthood that can result from 
      prenatal alcohol exposure. We recommend hearing evaluation be a part of any 
      long-term follow-up for FAS patients and patients exposed to any adverse prenatal 
      environment.
CI  - Copyright (c) 2011 by the Research Society on Alcoholism.
FAU - Church, Michael W
AU  - Church MW
AD  - Department of Obstetrics & Gynecology, Wayne State University School of Medicine, 
      Detroit, Michigan, USA. mchurch@med.wayne.edu
FAU - Hotra, John W
AU  - Hotra JW
FAU - Holmes, Pamela A
AU  - Holmes PA
FAU - Anumba, Jennifer I
AU  - Anumba JI
FAU - Jackson, Desmond A
AU  - Jackson DA
FAU - Adams, Brittany R
AU  - Adams BR
LA  - eng
GR  - R01 AA009991-03/AA/NIAAA NIH HHS/United States
GR  - R25 GM058905/GM/NIGMS NIH HHS/United States
GR  - AA09991-03/AA/NIAAA NIH HHS/United States
GR  - GM58905-08/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20110804
PL  - England
TA  - Alcohol Clin Exp Res
JT  - Alcoholism, clinical and experimental research
JID - 7707242
RN  - 3K9958V90M (Ethanol)
SB  - IM
MH  - Acoustic Stimulation
MH  - Age Factors
MH  - Animals
MH  - Animals, Newborn
MH  - Ethanol/*administration & dosage/*toxicity
MH  - Evoked Potentials, Auditory, Brain Stem/*drug effects
MH  - Female
MH  - Fetal Alcohol Spectrum Disorders/physiopathology
MH  - Longevity/*drug effects
MH  - Male
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/chemically induced/*physiopathology
MH  - Rats
MH  - Rats, Sprague-Dawley
PMC - PMC3210930
MID - NIHMS302767
EDAT- 2011/08/06 06:00
MHDA- 2012/08/25 06:00
PMCR- 2013/01/01
CRDT- 2011/08/06 06:00
PHST- 2011/08/06 06:00 [entrez]
PHST- 2011/08/06 06:00 [pubmed]
PHST- 2012/08/25 06:00 [medline]
PHST- 2013/01/01 00:00 [pmc-release]
AID - 10.1111/j.1530-0277.2011.01594.x [doi]
PST - ppublish
SO  - Alcohol Clin Exp Res. 2012 Jan;36(1):83-96. doi: 
      10.1111/j.1530-0277.2011.01594.x. Epub 2011 Aug 4.