PMID- 21816981
OWN - NLM
STAT- MEDLINE
DCOM- 20120511
LR  - 20211020
IS  - 1935-5548 (Electronic)
IS  - 0149-5992 (Print)
IS  - 0149-5992 (Linking)
VI  - 34
IP  - 9
DP  - 2011 Sep
TI  - Association between type 2 diabetes and exposure to persistent organic 
      pollutants.
PG  - 1972-9
LID - 10.2337/dc10-2303 [doi]
AB  - OBJECTIVE: The prevalence of type 2 diabetes is increasing alarmingly in both 
      developed and developing countries. Recently, exposure to persistent organic 
      pollutants (POPs) has been associated with the prevalence of type 2 diabetes. The 
      purpose of this cross-sectional study is to examine the association between type 
      2 diabetes and POP exposure in the Helsinki Birth Cohort Study. RESEARCH DESIGN 
      AND METHODS: The cohort consists of 8,760 people born in Helsinki during 
      1934-1944, before the global POP emission peak. In 2003, a clinical examination 
      was performed, including blood sampling for laboratory analyses of serum lipids 
      and POPs. Complete data from the examination were available for 1,988 
      participants. The concentrations of each POP were categorized into four groups on 
      the basis of percentile intervals, and logistic regression was performed to 
      examine diabetes prevalence across the POP categories, adjusting for sex, age, 
      waist circumference, and mean arterial pressure and using the lowest category as 
      the reference group. RESULTS: Among the participants with the highest exposure to 
      oxychlordane, trans-nonachlor, 1,1-dichloro-2,2-bis-(p-chlorophenyl)-ethylene 
      (p,p'-DDE, and polychlorinated biphenyl 153, the risk of type 2 diabetes was 
      1.64-2.24 times higher than that among individuals with the lowest exposure 
      (P(lin) = 0.003-0.050, where P(lin) is the P value for linear trend across POP 
      categories). In the stratified analysis, the associations between type 2 diabetes 
      and oxychlordane and trans-nonachlor remained significant and were strongest 
      among the overweight participants. Exposure to 2,2',4,4'-tetrabromodiphenyl ether 
      (BDE 47) and 2,2',4,4',5,5'-hexabromodiphenyl ether (BDE 153) was not associated 
      with type 2 diabetes. CONCLUSIONS: This study confirms the association between 
      type 2 diabetes and adult-only exposure to organochlorine pesticides in a general 
      urban population.
FAU - Airaksinen, Riikka
AU  - Airaksinen R
AD  - Department of Environmental Health, National Institute for Health and Welfare, 
      Kuopio, Finland. riikka.airaksinen@thl.fi
FAU - Rantakokko, Panu
AU  - Rantakokko P
FAU - Eriksson, Johan G
AU  - Eriksson JG
FAU - Blomstedt, Paul
AU  - Blomstedt P
FAU - Kajantie, Eero
AU  - Kajantie E
FAU - Kiviranta, Hannu
AU  - Kiviranta H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110804
PL  - United States
TA  - Diabetes Care
JT  - Diabetes care
JID - 7805975
RN  - 0 (Environmental Pollutants)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 4M7FS82U08 (Dichlorodiphenyl Dichloroethylene)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Aged
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/*chemically induced/*epidemiology
MH  - Dichlorodiphenyl Dichloroethylene/toxicity
MH  - Environmental Pollutants/*toxicity
MH  - Female
MH  - Humans
MH  - Hydrocarbons, Chlorinated/*toxicity
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Polychlorinated Biphenyls/toxicity
PMC - PMC3161294
EDAT- 2011/08/06 06:00
MHDA- 2012/05/12 06:00
PMCR- 2012/09/01
CRDT- 2011/08/06 06:00
PHST- 2011/08/06 06:00 [entrez]
PHST- 2011/08/06 06:00 [pubmed]
PHST- 2012/05/12 06:00 [medline]
PHST- 2012/09/01 00:00 [pmc-release]
AID - dc10-2303 [pii]
AID - 2303 [pii]
AID - 10.2337/dc10-2303 [doi]
PST - ppublish
SO  - Diabetes Care. 2011 Sep;34(9):1972-9. doi: 10.2337/dc10-2303. Epub 2011 Aug 4.