PMID- 21818296
OWN - NLM
STAT- MEDLINE
DCOM- 20111206
LR  - 20211020
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 6
IP  - 7
DP  - 2011
TI  - The TNF-alpha-238 polymorphism and cancer risk: a meta-analysis.
PG  - e22092
LID - 10.1371/journal.pone.0022092 [doi]
LID - e22092
AB  - BACKGROUND AND OBJECTIVES: Tumor necrosis factor-alpha (TNF-alpha) plays a very important 
      role in the development and progress of cancer. Some TNF-alpha polymorphisms have 
      been confirmed to increase cancer risks; however, the association between 
      TNF-alpha-238 polymorphism and cancers remains controversial and ambiguous. The aim 
      of this study is to explore a more precise estimation of its relationship with 
      cancer using meta-analysis. METHODS: Electronic searches of several databases 
      were conducted for all publications on the association between this variant and 
      cancer through March 2011. Odds ratios (OR) with 95% confidence intervals (95% 
      CI) were used to access the strength of this association in the random-effect 
      model. RESULTS: Thirty four studies with 34,679 cancer patients and 41,186 
      healthy controls were included. This meta-analysis showed no significant 
      association between TNF-alpha-238 polymorphism and cancers (AA+GA vs GG: OR = 1.09, 
      95%CI = 0.88-1.34). In Caucasian and Asian subgroups, OR values (95% CI) were 
      1.14 (0.91-1.43) and 0.97 (0.58-1.61), respectively. In the subgroups of cancer 
      type, no significant association was detected. The sensitivity analysis further 
      strengthened the validity of these negative associations. No publication bias was 
      observed in this study. CONCLUSIONS: No significant association was found between 
      the TNF-alpha-238 polymorphism and the risk for cancer.
FAU - Zhou, Ping
AU  - Zhou P
AD  - Department of General Surgery, The Third Affiliated Hospital to Nantong 
      University, Wuxi, China.
FAU - Lv, Guo-Qiang
AU  - Lv GQ
FAU - Wang, Jian-Zhong
AU  - Wang JZ
FAU - Li, Cheng-Wan
AU  - Li CW
FAU - Du, Liang-Feng
AU  - Du LF
FAU - Zhang, Chun
AU  - Zhang C
FAU - Li, Jian-Ping
AU  - Li JP
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20110719
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Confidence Intervals
MH  - *Genetic Predisposition to Disease
MH  - Humans
MH  - Models, Genetic
MH  - Neoplasms/*genetics
MH  - Odds Ratio
MH  - *Polymorphism, Genetic
MH  - Publication Bias
MH  - Risk Factors
MH  - Tumor Necrosis Factor-alpha/*genetics
PMC - PMC3139602
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2011/08/06 06:00
MHDA- 2011/12/13 00:00
PMCR- 2011/07/19
CRDT- 2011/08/06 06:00
PHST- 2011/03/30 00:00 [received]
PHST- 2011/06/15 00:00 [accepted]
PHST- 2011/08/06 06:00 [entrez]
PHST- 2011/08/06 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
PHST- 2011/07/19 00:00 [pmc-release]
AID - PONE-D-11-05783 [pii]
AID - 10.1371/journal.pone.0022092 [doi]
PST - ppublish
SO  - PLoS One. 2011;6(7):e22092. doi: 10.1371/journal.pone.0022092. Epub 2011 Jul 19.