PMID- 21819545
OWN - NLM
STAT- MEDLINE
DCOM- 20120203
LR  - 20220408
IS  - 1743-6109 (Electronic)
IS  - 1743-6095 (Linking)
VI  - 8
IP  - 10
DP  - 2011 Oct
TI  - Comparing effects of a low-energy diet and a high-protein low-fat diet on sexual 
      and endothelial function, urinary tract symptoms, and inflammation in obese 
      diabetic men.
PG  - 2868-75
LID - 10.1111/j.1743-6109.2011.02417.x [doi]
AB  - INTRODUCTION: Abdominal obesity and type 2 diabetes mellitus are associated with 
      sexual and endothelial dysfunction, lower urinary tract symptoms (LUTS), and 
      chronic systemic inflammation. AIM: To determine the effects of diet-induced 
      weight loss and maintenance on sexual and endothelial function, LUTS, and 
      inflammatory markers in obese diabetic men. MAIN OUTCOME MEASURES: Weight, waist 
      circumference (WC), International Index of Erectile Function (IIEF-5) score, 
      Sexual Desire Inventory (SDI) score, International Prostate Symptom Scale (IPSS) 
      score, plasma fasting glucose and lipids, testosterone, sex hormone binding 
      globulin (SHBG), inflammatory markers (high-sensitivity C-reactive protein [CRP] 
      and interleukin-6 [IL-6]) and soluble E-selectin, and brachial artery 
      flow-mediated dilatation (FMD) were measured at baseline, 8 weeks, and 52 weeks. 
      METHODS: Over 8 weeks, 31 abdominally obese (body mass index >/= 30 kg/m(2) , WC >/= 
      102 cm), type 2 diabetic men (mean age 59.7 years) received either a meal 
      replacement-based low-calorie diet (LCD)  approximately 1,000 kcal/day (N = 19) or low-fat, 
      high-protein, reduced-carbohydrate (HP) diet (N = 12) prescribed to decrease 
      intake by  approximately 600 kcal/day. Subjects continued on, or were switched to, the HP diet 
      for another 44 weeks. RESULTS: At 8 weeks, weight and WC decreased by  approximately 10% and 
       approximately 5% with the LCD and HP diet, respectively. Both diets significantly improved 
      plasma glucose, low-density lipoprotein (LDL), SHBG, IIEF-5, SDI and IPSS scores, 
      and endothelial function (increased FMD, reduced soluble E-selectin). Erectile 
      function, sexual desire, and urinary symptoms improved by a similar degree with 
      both diets. CRP and IL-6 decreased with the HP diet. At 52 weeks, reductions in 
      weight, WC, and CRP were maintained. IIEF-5, SDI, and IPSS scores improved 
      further. CONCLUSIONS: Diet-induced weight loss induces rapid improvement of 
      sexual, urinary, and endothelial function in obese diabetic men. A high-protein, 
      carbohydrate-reduced, low-fat diet also reduces systemic inflammation and 
      sustains these beneficial effects to 1 year.
CI  - (c) 2011 International Society for Sexual Medicine.
FAU - Khoo, Joan
AU  - Khoo J
AD  - Department of Endocrinology, Changi General Hospital, Singapore, Singapore. 
      furrina_2000@yahoo.com
FAU - Piantadosi, Cynthia
AU  - Piantadosi C
FAU - Duncan, Rae
AU  - Duncan R
FAU - Worthley, Stephen G
AU  - Worthley SG
FAU - Jenkins, Alicia
AU  - Jenkins A
FAU - Noakes, Manny
AU  - Noakes M
FAU - Worthley, Matthew I
AU  - Worthley MI
FAU - Lange, Kylie
AU  - Lange K
FAU - Wittert, Gary A
AU  - Wittert GA
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20110805
PL  - Netherlands
TA  - J Sex Med
JT  - The journal of sexual medicine
JID - 101230693
RN  - 0 (Blood Glucose)
RN  - 0 (E-Selectin)
RN  - 0 (Interleukin-6)
RN  - 0 (Lipids)
RN  - 0 (Sex Hormone-Binding Globulin)
RN  - 3XMK78S47O (Testosterone)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Blood Glucose/analysis
MH  - Body Mass Index
MH  - C-Reactive Protein/analysis
MH  - *Caloric Restriction
MH  - Diabetes Mellitus, Type 2/*drug therapy
MH  - *Diet, Fat-Restricted
MH  - E-Selectin/blood
MH  - Humans
MH  - Inflammation/*diet therapy
MH  - Interleukin-6/blood
MH  - Libido/physiology
MH  - Lipids/blood
MH  - Male
MH  - Middle Aged
MH  - Obesity/*diet therapy
MH  - *Penile Erection/physiology
MH  - Prostate/physiopathology
MH  - Sex Hormone-Binding Globulin/analysis
MH  - Testosterone/blood
MH  - Urologic Diseases/*drug therapy
MH  - Waist Circumference
EDAT- 2011/08/09 06:00
MHDA- 2012/02/04 06:00
CRDT- 2011/08/09 06:00
PHST- 2011/08/09 06:00 [entrez]
PHST- 2011/08/09 06:00 [pubmed]
PHST- 2012/02/04 06:00 [medline]
AID - S1743-6095(15)33283-5 [pii]
AID - 10.1111/j.1743-6109.2011.02417.x [doi]
PST - ppublish
SO  - J Sex Med. 2011 Oct;8(10):2868-75. doi: 10.1111/j.1743-6109.2011.02417.x. Epub 
      2011 Aug 5.