PMID- 21819870
OWN - NLM
STAT- MEDLINE
DCOM- 20111123
LR  - 20151119
IS  - 1873-4324 (Electronic)
IS  - 0003-2670 (Linking)
VI  - 702
IP  - 1
DP  - 2011 Sep 19
TI  - Enantioselective determination of triazole fungicide simeconazole in vegetables, 
      fruits, and cereals using modified QuEChERS (quick, easy, cheap, effective, 
      rugged and safe) coupled to gas chromatography/tandem mass spectrometry.
PG  - 127-35
LID - 10.1016/j.aca.2011.06.034 [doi]
AB  - A rapid and effective method for enantioselective determination of simeconazole 
      enantiomers in food products (cucumber, tomato, apple, pear, wheat and rice) has 
      been developed. The enantiomers were resolved by capillary gas chromatography 
      (GC) using a commercial chiral column (BGB-172) and a temperature program from 
      150 degrees C (held for 1 min) and then raised at 10 degrees C min(-1) to 240 degrees C (held for 10 
      min). This enantioselective gas chromatographic separation was combined with a 
      clean-up/enrichment procedure based on the modification of QuEChERS (quick, easy, 
      cheap, effective, rugged and safe) method. Co-extractives were removed with 
      graphitized carbon black/primary secondary amine (GCB/PSA) solid-phase extraction 
      (SPE) cartridges using acetonitrile:toluene (3:1, v/v) as eluent. Gas 
      chromatography/ion trap mass spectrometry (GC-ITMS) with electron ionization (EI) 
      was then used for qualitative and quantitative determination of the simeconazole 
      enantiomers. Two precursor-to-product ion transitions (m/z 121-101 and 195-153) 
      with the best signal intensity were chosen to build the multiple-reaction 
      monitoring (MRM) acquisition method. The limits of detection for each enantiomer 
      of simeconazole in six food products ranged between 0.4 and 0.9 mug kg(-1), which 
      were much lower than maximum residue levels (MRLs) established by Japan. The 
      methodology was successfully applied for the enantioselective analysis of 
      simeconazole enantiomers in real samples, indicating its efficacy in 
      investigating the environmental stereochemistry of simeconazole in food matrix.
CI  - Copyright (c) 2011 Elsevier B.V. All rights reserved.
FAU - Li, Jing
AU  - Li J
AD  - Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Key 
      Laboratory of Pesticide Chemistry and Application, Ministry of Agriculture, 
      Beijing, 100193, China. lijing2011@gmail.com
FAU - Dong, Fengshou
AU  - Dong F
FAU - Xu, Jun
AU  - Xu J
FAU - Liu, Xingang
AU  - Liu X
FAU - Li, Yuanbo
AU  - Li Y
FAU - Shan, Weili
AU  - Shan W
FAU - Zheng, Yongquan
AU  - Zheng Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110629
PL  - Netherlands
TA  - Anal Chim Acta
JT  - Analytica chimica acta
JID - 0370534
RN  - 0 (2-(4-fluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-3-trimethylsilylpropan-2-ol)
RN  - 0 (Antifungal Agents)
RN  - 0 (Pesticide Residues)
RN  - 0 (Triazoles)
RN  - 0 (Trimethylsilyl Compounds)
SB  - IM
MH  - Antifungal Agents/analysis
MH  - Chromatography, Gas/*methods
MH  - Edible Grain/*chemistry
MH  - Food Analysis/*methods
MH  - Food Contamination/analysis
MH  - Fruit/*chemistry
MH  - Gas Chromatography-Mass Spectrometry/methods
MH  - Limit of Detection
MH  - Pesticide Residues/analysis
MH  - Quality Control
MH  - Sensitivity and Specificity
MH  - Solid Phase Extraction
MH  - Tandem Mass Spectrometry/*methods
MH  - Triazoles/*analysis
MH  - Trimethylsilyl Compounds/*analysis
MH  - Vegetables/*chemistry
EDAT- 2011/08/09 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/08/09 06:00
PHST- 2011/03/12 00:00 [received]
PHST- 2011/06/06 00:00 [revised]
PHST- 2011/06/19 00:00 [accepted]
PHST- 2011/08/09 06:00 [entrez]
PHST- 2011/08/09 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - S0003-2670(11)00863-4 [pii]
AID - 10.1016/j.aca.2011.06.034 [doi]
PST - ppublish
SO  - Anal Chim Acta. 2011 Sep 19;702(1):127-35. doi: 10.1016/j.aca.2011.06.034. Epub 
      2011 Jun 29.