PMID- 21820073
OWN - NLM
STAT- MEDLINE
DCOM- 20120325
LR  - 20170309
IS  - 1522-9629 (Electronic)
IS  - 1094-5539 (Linking)
VI  - 24
IP  - 6
DP  - 2011 Dec
TI  - 17beta-Estradiol administration attenuates seawater aspiration-induced acute lung 
      injury in rats.
PG  - 673-81
LID - 10.1016/j.pupt.2011.07.002 [doi]
AB  - There is very little evidence on the value of administering estrogen in cases of 
      seawater drowning which can induce acute lung injury/acute respiratory distress 
      syndrome (ALI/ARDS). Therefore, this study aimed to investigate whether 
      17beta-estradiol (E2) treatment can attenuate seawater aspiration-induced ALI in 
      rats. In the experiment, ALI was induced by endotracheal instillation of seawater 
      (4mL/kg) and the rats were then given intraperitoneal injection of E2 (5mg/kg) 
      20min after seawater instillation. Finally, the changes of arterial blood gases 
      which contained hydrogen ion concentration (pH), arterial oxygen tension (PaO(2)) 
      and arterial carbon dioxide tension (PaCO(2)) were measured and the measurement 
      of extravascular lung water (EVLW) was observed. The pulmonary histological 
      changes were evaluated by hematoxylin-eosin stain. The expression of aquaporins 
      (AQPs) 1, AQP5, and estrogen receptor-beta (ERbeta) was measured by western blotting 
      and immunohistochemical methods. The results showed that compared with normal 
      saline water, seawater aspiration induced more serious ALI in rats which was 
      markedly alleviated by E2 treatment. Meanwhile, the ERbeta in lung tissues was 
      activated after E2 administration. The seawater aspiration group also presented 
      with severe pulmonary edema which was paralleled with over expressed AQP1 and 
      AQP5. However, the up-regulation of AQP1 and AQP5 was suppressed by the 
      administration of E2, resulting in an attenuation of lung edema. In conclusion, 
      E2 treatment could effectively attenuate seawater aspiration-induced acute lung 
      injury in rats by the down-regulation of AQP1 and AQP5.
CI  - Copyright A(c) 2011 Elsevier Ltd. All rights reserved.
FAU - Fan, Qixin
AU  - Fan Q
AD  - Department of Respiratory Medicine, Tangdu Hospital, Fourth Military Medical 
      University, Xi'an, PR China.
FAU - Zhao, Pengtao
AU  - Zhao P
FAU - Li, Jiahuan
AU  - Li J
FAU - Xie, Xiaoyan
AU  - Xie X
FAU - Xu, Min
AU  - Xu M
FAU - Zhang, Yong
AU  - Zhang Y
FAU - Mu, Deguang
AU  - Mu D
FAU - Li, Wangping
AU  - Li W
FAU - Sun, Ruilin
AU  - Sun R
FAU - Liu, Wei
AU  - Liu W
FAU - Nan, Yandong
AU  - Nan Y
FAU - Zhang, Bo
AU  - Zhang B
FAU - Jin, Faguang
AU  - Jin F
FAU - Li, Zhichao
AU  - Li Z
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110727
PL  - England
TA  - Pulm Pharmacol Ther
JT  - Pulmonary pharmacology & therapeutics
JID - 9715279
RN  - 0 (Aqp1 protein, mouse)
RN  - 0 (Aqp5 protein, mouse)
RN  - 0 (Aquaporin 5)
RN  - 0 (Estrogen Receptor beta)
RN  - 142M471B3J (Carbon Dioxide)
RN  - 146410-94-8 (Aquaporin 1)
RN  - 4TI98Z838E (Estradiol)
SB  - IM
MH  - Acute Lung Injury/*drug therapy/metabolism/pathology
MH  - Animals
MH  - Aquaporin 1/analysis
MH  - Aquaporin 5/analysis
MH  - Carbon Dioxide/blood
MH  - Estradiol/*therapeutic use
MH  - Estrogen Receptor beta/analysis
MH  - Extravascular Lung Water/drug effects
MH  - Lung/pathology
MH  - Male
MH  - Near Drowning/*therapy
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Seawater/*adverse effects
EDAT- 2011/08/09 06:00
MHDA- 2012/03/27 06:00
CRDT- 2011/08/09 06:00
PHST- 2011/02/05 00:00 [received]
PHST- 2011/07/08 00:00 [revised]
PHST- 2011/07/14 00:00 [accepted]
PHST- 2011/08/09 06:00 [entrez]
PHST- 2011/08/09 06:00 [pubmed]
PHST- 2012/03/27 06:00 [medline]
AID - S1094-5539(11)00122-2 [pii]
AID - 10.1016/j.pupt.2011.07.002 [doi]
PST - ppublish
SO  - Pulm Pharmacol Ther. 2011 Dec;24(6):673-81. doi: 10.1016/j.pupt.2011.07.002. Epub 
      2011 Jul 27.