PMID- 21820366
OWN - NLM
STAT- MEDLINE
DCOM- 20111024
LR  - 20151119
IS  - 1873-376X (Electronic)
IS  - 1570-0232 (Linking)
VI  - 879
IP  - 25
DP  - 2011 Sep 1
TI  - A new way of solid-phase microextraction fibers preparation for selected 
      antibiotic drug determination by HPLC-MS.
PG  - 2542-8
LID - 10.1016/j.jchromb.2011.07.007 [doi]
AB  - The polypyrrole (PPy) and polythiophene (PTh) solid phase microextraction (SPME) 
      coatings were obtained with the use of the electropolymerisation and linear sweep 
      voltammetry. Such fibers were modified by an ozone treatment in a gaseous phase 
      in the concentration of 2.1 +/- 0.2 x 10(-5) mol dm(-3). Both kinds of fibers were 
      applied in the microextraction of linezolid from standard solutions to compare 
      the extraction efficiencies displayed by these sorption phases. In these 
      investigations a better adsorption capacity was obtained for polypyrrole fibers 
      and hence only these kinds of fibers were utilized in the measurements from human 
      plasma. In all measurements the concentrations of the drugs were in the range 
      from 1 to 20 mug ml(-1) (standard solutions) and 1 to 15 mug ml(-1) (human plasma). 
      Before the measurements, an optimization of the desorption solution experiments 
      was performed. The correlation coefficients (R) obtained in the standard solution 
      and human plasma were in the range from 0.8399 to 0.9970. The relative standard 
      deviations (RSDs) were in the range of 0.1-7.6%.
CI  - Copyright (c) 2011 Elsevier B.V. All rights reserved.
FAU - Olszowy, Pawel
AU  - Olszowy P
AD  - Department of Environmental Chemistry and Bioanalytics, Faculty of Chemistry, 
      Nicolaus Copernicus University, Gagarin 7, 87-100 Torun, Poland.
FAU - Szultka, Malgorzata
AU  - Szultka M
FAU - Nowaczyk, Jacek
AU  - Nowaczyk J
FAU - Buszewski, Boguslaw
AU  - Buszewski B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110718
PL  - Netherlands
TA  - J Chromatogr B Analyt Technol Biomed Life Sci
JT  - Journal of chromatography. B, Analytical technologies in the biomedical and life 
      sciences
JID - 101139554
RN  - 0 (Acetamides)
RN  - 0 (Anti-Infective Agents)
RN  - 0 (Oxazolidinones)
RN  - 0 (Polymers)
RN  - 0 (Pyrroles)
RN  - 0 (Thiophenes)
RN  - 25233-34-5 (polythiophene)
RN  - 30604-81-0 (polypyrrole)
RN  - 66H7ZZK23N (Ozone)
RN  - ISQ9I6J12J (Linezolid)
SB  - IM
MH  - Acetamides/analysis
MH  - Anti-Infective Agents/*analysis
MH  - Chromatography, High Pressure Liquid/*methods
MH  - Humans
MH  - Linear Models
MH  - Linezolid
MH  - Mass Spectrometry/*methods
MH  - Models, Chemical
MH  - Oxazolidinones/analysis
MH  - Ozone
MH  - Polymers/chemistry
MH  - Pyrroles/chemistry
MH  - Reproducibility of Results
MH  - Solid Phase Microextraction/*instrumentation
MH  - Thiophenes/chemistry
EDAT- 2011/08/09 06:00
MHDA- 2011/10/25 06:00
CRDT- 2011/08/09 06:00
PHST- 2011/03/03 00:00 [received]
PHST- 2011/06/01 00:00 [revised]
PHST- 2011/07/07 00:00 [accepted]
PHST- 2011/08/09 06:00 [entrez]
PHST- 2011/08/09 06:00 [pubmed]
PHST- 2011/10/25 06:00 [medline]
AID - S1570-0232(11)00458-2 [pii]
AID - 10.1016/j.jchromb.2011.07.007 [doi]
PST - ppublish
SO  - J Chromatogr B Analyt Technol Biomed Life Sci. 2011 Sep 1;879(25):2542-8. doi: 
      10.1016/j.jchromb.2011.07.007. Epub 2011 Jul 18.