PMID- 21820460
OWN - NLM
STAT- MEDLINE
DCOM- 20111027
LR  - 20131121
IS  - 1096-0333 (Electronic)
IS  - 0041-008X (Linking)
VI  - 255
IP  - 3
DP  - 2011 Sep 15
TI  - Distribution of bisphenol A into tissues of adult, neonatal, and fetal 
      Sprague-Dawley rats.
PG  - 261-70
LID - 10.1016/j.taap.2011.07.009 [doi]
AB  - Bisphenol A (BPA) is an important industrial chemical used in the manufacture of 
      polycarbonate plastic products and epoxy resin-based food can liners. The 
      presence of BPA metabolites in urine of >90% of Americans aged 6-60 suggests 
      ubiquitous and frequent exposure in the range of 0.02-0.2mug/kgbw/d (25th-95th 
      percentiles). The current study used LC/MS/MS to measure placental transfer and 
      concentrations of aglycone (receptor-active) and conjugated (inactive) BPA in 
      tissues from Sprague-Dawley rats administered deuterated BPA (100mug/kg bw) by 
      oral and IV routes. In adult female rat tissues, the tissue/serum concentration 
      ratios for aglycone BPA ranged from 0.7 in liver to 5 in adipose tissue, 
      reflecting differences in tissue perfusion, composition, and metabolic capacity. 
      Following IV administration to dams, placental transfer was observed for aglycone 
      BPA into fetuses at several gestational days (GD), with fetal/maternal serum 
      ratios of 2.7 at GD 12, 1.2 at GD 16, and 0.4 at GD 20; the corresponding ratios 
      for conjugated BPA were 0.43, 0.65, and 3.7. These ratios were within the ranges 
      observed in adult tissues and were not indicative of preferential accumulation of 
      aglycone BPA or hydrolysis of conjugates in fetal tissue in vivo. Concentrations 
      of aglycone BPA in GD 20 fetal brain were higher than in liver or serum. Oral 
      administration of the same dose did not produce measurable levels of aglycone BPA 
      in fetal tissues. Amniotic fluid consistently contained levels of BPA at or below 
      those in maternal serum. Concentrations of aglycone BPA in tissues of neonatal 
      rats decreased with age in a manner consistent with the corresponding circulating 
      levels. Phase II metabolism of BPA increased with fetal age such that near-term 
      fetus was similar to early post-natal rats. These results show that 
      concentrations of aglycone BPA in fetal tissues are similar to those in other 
      maternal and neonatal tissues and that maternal Phase II metabolism, especially 
      following oral administration, and fetal age are critical in reducing exposures 
      to the fetus.
CI  - Published by Elsevier Inc.
FAU - Doerge, Daniel R
AU  - Doerge DR
AD  - Division of Biochemical Toxicology, National Center for Toxicological Research, 
      U.S. Food and Drug Administration, Jefferson, AR 72079, USA. 
      daniel.doerge@fda.hhs.gov
FAU - Twaddle, Nathan C
AU  - Twaddle NC
FAU - Vanlandingham, Michelle
AU  - Vanlandingham M
FAU - Brown, Ronald P
AU  - Brown RP
FAU - Fisher, Jeffrey W
AU  - Fisher JW
LA  - eng
GR  - Y1ES1027/ES/NIEHS NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20110722
PL  - United States
TA  - Toxicol Appl Pharmacol
JT  - Toxicology and applied pharmacology
JID - 0416575
RN  - 0 (Benzhydryl Compounds)
RN  - 0 (Phenols)
RN  - MLT3645I99 (bisphenol A)
SB  - IM
MH  - Age Factors
MH  - Amniotic Fluid/drug effects/metabolism
MH  - Animals
MH  - Animals, Newborn
MH  - Benzhydryl Compounds
MH  - Female
MH  - Fetus/drug effects/*metabolism
MH  - Maternal-Fetal Exchange/drug effects/*physiology
MH  - Phenols/*metabolism/toxicity
MH  - Pregnancy
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Tissue Distribution/drug effects/physiology
EDAT- 2011/08/09 06:00
MHDA- 2011/10/28 06:00
CRDT- 2011/08/09 06:00
PHST- 2011/06/16 00:00 [received]
PHST- 2011/07/13 00:00 [revised]
PHST- 2011/07/14 00:00 [accepted]
PHST- 2011/08/09 06:00 [entrez]
PHST- 2011/08/09 06:00 [pubmed]
PHST- 2011/10/28 06:00 [medline]
AID - S0041-008X(11)00269-9 [pii]
AID - 10.1016/j.taap.2011.07.009 [doi]
PST - ppublish
SO  - Toxicol Appl Pharmacol. 2011 Sep 15;255(3):261-70. doi: 
      10.1016/j.taap.2011.07.009. Epub 2011 Jul 22.