PMID- 2182099
OWN - NLM
STAT- MEDLINE
DCOM- 19900518
LR  - 20190704
IS  - 0007-0963 (Print)
IS  - 0007-0963 (Linking)
VI  - 122
IP  - 3
DP  - 1990 Mar
TI  - Recombinant interferon alpha 2a is effective in the treatment of discoid and 
      subacute cutaneous lupus erythematosus.
PG  - 405-9
AB  - Ten patients suffering from either discoid lupus erythematosus (DLE) or subacute 
      cutaneous lupus erythematosus (SCLE) were treated with interferon alpha 2a. Eight 
      received low or intermediate doses (18-45 x 10(6) U/week) for a short period of 
      time (4-8 weeks), with marked improvement of skin lesions in six, an exacerbation 
      in one patient and no change in the other. Two patients with SCLE received high 
      doses (100-120 x 10(6) U/week) over 12 weeks, with complete clearing of the 
      lesions in one and a marked improvement in the other. The responses were of short 
      duration and within a few weeks of stopping treatment all who had improved or 
      cleared relapsed. The side-effects in all the patients were fever and a flu-like 
      syndrome which necessitated a reduction of the dose in one case. In two patients 
      there were increases in the liver enzyme levels, but no haematological toxicity 
      was noted.
FAU - Thivolet, J
AU  - Thivolet J
AD  - Clinique Dermatologique, Hopital E. Herriot, Lyon, France.
FAU - Nicolas, J F
AU  - Nicolas JF
FAU - Kanitakis, J
AU  - Kanitakis J
FAU - Lyonnet, S
AU  - Lyonnet S
FAU - Chouvet, B
AU  - Chouvet B
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PL  - England
TA  - Br J Dermatol
JT  - The British journal of dermatology
JID - 0004041
RN  - 0 (Interferon Type I)
RN  - 0 (Interferon alpha-2)
RN  - 0 (Interferon-alpha)
RN  - 0 (Recombinant Proteins)
SB  - IM
MH  - Adult
MH  - Clinical Trials as Topic
MH  - Drug Administration Schedule
MH  - Female
MH  - Humans
MH  - Interferon Type I/*therapeutic use
MH  - Interferon alpha-2
MH  - Interferon-alpha/administration & dosage/*therapeutic use
MH  - Lupus Erythematosus, Cutaneous/*therapy
MH  - Lupus Erythematosus, Discoid/*therapy
MH  - Male
MH  - Middle Aged
MH  - Recombinant Proteins
EDAT- 1990/03/01 00:00
MHDA- 1990/03/01 00:01
CRDT- 1990/03/01 00:00
PHST- 1990/03/01 00:00 [pubmed]
PHST- 1990/03/01 00:01 [medline]
PHST- 1990/03/01 00:00 [entrez]
AID - 10.1111/j.1365-2133.1990.tb08290.x [doi]
PST - ppublish
SO  - Br J Dermatol. 1990 Mar;122(3):405-9. doi: 10.1111/j.1365-2133.1990.tb08290.x.