PMID- 21821059
OWN - NLM
STAT- MEDLINE
DCOM- 20111129
LR  - 20131121
IS  - 1096-0333 (Electronic)
IS  - 0041-008X (Linking)
VI  - 256
IP  - 2
DP  - 2011 Oct 15
TI  - Altered cardiovascular reactivity and osmoregulation during hyperosmotic stress 
      in adult rats developmentally exposed to polybrominated diphenyl ethers (PBDEs).
PG  - 103-13
LID - 10.1016/j.taap.2011.07.014 [doi]
AB  - Polybrominated diphenyl ethers (PBDEs) and the structurally similar chemicals 
      polychlorinated biphenyls (PCBs) disrupt the function of multiple endocrine 
      systems. PCBs and PBDEs disrupt the secretion of vasopressin (VP) from the 
      hypothalamus during osmotic activation. Since the peripheral and central 
      vasopressinergic axes are critical for osmotic and cardiovascular regulation, we 
      examined whether perinatal PBDE exposure could impact these functions during 
      physiological activation. Rats were perinatally dosed with a commercial PBDE 
      mixture, DE-71. Dams were given 0 (corn oil control), 1.7 (low dose) or 30.6 
      mg/kg/day (high dose) in corn oil from gestational day (GD) 6 through postnatal 
      day (PND) 21 by oral gavage. In the male offspring exposed to high dose PBDE 
      plasma thyroxine and triiodothyronine levels were reduced at PND 21 and recovered 
      to control levels by PND 60 when thyroid stimulating hormone levels were 
      elevated. At 14-18 months of age, cardiovascular responses were measured in four 
      groups of rats: Normal (Oil, normosmotic condition), Hyper (Oil, hyperosmotic 
      stress), Hyper PBDE low (1.7 mg/kg/day DE-71 perinatally, hyperosmotic stress), 
      and Hyper PBDE high (30.6 mg/kg/day DE-71 perinatally, hyperosmotic stress). 
      Systolic blood pressure (BP), diastolic BP, and heart rate (HR) were determined 
      using tail cuff sphygmomanometry and normalized to pretreatment values (baseline) 
      measured under basal conditions. Hyperosmotic treatment yielded significant 
      changes in systolic BP in PBDE exposed rats only. Hyper PBDE low and high dose 
      rats showed 36.1 and 64.7% greater systolic BP responses at 3h post hyperosmotic 
      injection relative to pretreatment baseline, respectively. No treatment effects 
      were measured for diastolic BP and HR. Hyper and Hyper PBDE rats showed increased 
      mean plasma osmolality values by 45 min after injection relative to normosmotic 
      controls. In contrast to Hyper rats, Hyper PBDE (high) rats showed a further 
      increase in mean plasma osmolality at 3h (358.3+/-12.4mOsm/L) relative to 45 min 
      post hyperosmotic injection (325.1+/-11.4mOsm/L). Impaired osmoregulation in 
      PBDE-treated animals could not be attributed to decreased levels of plasma 
      vasopressin. Our findings suggest that developmental exposure to PBDEs may 
      disrupt cardiovascular reactivity and osmoregulatory responses to physiological 
      activation in late adulthood.
CI  - Copyright (c) 2011. Published by Elsevier Inc.
FAU - Shah, Ashini
AU  - Shah A
AD  - Department of Cell Biology and Neuroscience, University of California, Riverside, 
      CA 92521, USA.
FAU - Coburn, Cary G
AU  - Coburn CG
FAU - Watson-Siriboe, Abena
AU  - Watson-Siriboe A
FAU - Whitley, Rebecca
AU  - Whitley R
FAU - Shahidzadeh, Anoush
AU  - Shahidzadeh A
FAU - Gillard, Elizabeth R
AU  - Gillard ER
FAU - Nichol, Robert
AU  - Nichol R
FAU - Leon-Olea, Martha
AU  - Leon-Olea M
FAU - Gaertner, Mark
AU  - Gaertner M
FAU - Kodavanti, Prasada Rao S
AU  - Kodavanti PR
FAU - Curras-Collazo, Margarita C
AU  - Curras-Collazo MC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20110729
PL  - United States
TA  - Toxicol Appl Pharmacol
JT  - Toxicology and applied pharmacology
JID - 0416575
RN  - 0 (Halogenated Diphenyl Ethers)
RN  - 06LU7C9H1V (Triiodothyronine)
RN  - 11000-17-2 (Vasopressins)
RN  - 9002-71-5 (Thyrotropin)
RN  - Q51BO43MG4 (Thyroxine)
SB  - IM
MH  - Age Factors
MH  - Animals
MH  - Animals, Newborn
MH  - Blood Pressure/drug effects
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Halogenated Diphenyl Ethers/*adverse effects
MH  - Male
MH  - Osmotic Pressure/*drug effects
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/physiopathology
MH  - Rats
MH  - Rats, Long-Evans
MH  - Thyrotropin/blood
MH  - Thyroxine/blood
MH  - Triiodothyronine/blood
MH  - Vasopressins/blood
MH  - Water-Electrolyte Balance/*drug effects
EDAT- 2011/08/09 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/08/09 06:00
PHST- 2010/10/28 00:00 [received]
PHST- 2011/07/19 00:00 [revised]
PHST- 2011/07/21 00:00 [accepted]
PHST- 2011/08/09 06:00 [entrez]
PHST- 2011/08/09 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - S0041-008X(11)00283-3 [pii]
AID - 10.1016/j.taap.2011.07.014 [doi]
PST - ppublish
SO  - Toxicol Appl Pharmacol. 2011 Oct 15;256(2):103-13. doi: 
      10.1016/j.taap.2011.07.014. Epub 2011 Jul 29.