PMID- 21821227
OWN - NLM
STAT- MEDLINE
DCOM- 20111129
LR  - 20151119
IS  - 1879-1913 (Electronic)
IS  - 0002-9149 (Linking)
VI  - 108
IP  - 8
DP  - 2011 Oct 15
TI  - Effect of cardiac resynchronization therapy-defibrillator implantation on health 
      status in patients with mild versus moderate symptoms of heart failure.
PG  - 1155-9
LID - 10.1016/j.amjcard.2011.06.019 [doi]
AB  - Indications for cardiac resynchronization therapy (CRT) have expanded to include 
      patients with mild congestive heart failure (CHF) symptoms (New York Heart 
      Association [NYHA] functional class II) because of a demonstrated morbidity 
      reduction in this subset of patients. However, little is known about 
      postimplantation changes in their self-reported health status compared to 
      patients with more severe CHF. The aim of this study was to examine the influence 
      of baseline NYHA functional class on health status changes in the first 12 months 
      after implantation of a CRT with defibrillator (CRT-D). Patients with first-time 
      CRT-D (n = 169, 75% men, mean age 62.1 +/- 10.7 years) were recruited from 3 Dutch 
      hospitals. All patients completed the SF-36 Health Survey at the time of 
      implantation and at 12 months after implantation. Mildly (NYHA functional class 
      II; n = 54) and moderately (NYHA functional class III; n = 115) symptomatic CHF 
      patients showed improved health status in several SF-36 domains at 12 months 
      after CRT-D. When adjusting for baseline health status, the groups did not differ 
      with respect to their health status improvement over time, but after adjustment 
      for demographic and clinical factors, the mildly symptomatic patients reported 
      relatively more improvement in general health (B = 10.15, SE = 3.31, p = 0.003) 
      and social functioning (B = 10.64, SE = 3.74, p = 0.005). In conclusion, NYHA 
      functional class II patients reported equal, and in some domains even more, 
      improvement in health status compared to NYHA functional class III patients at 12 
      months after CRT-D. Hence, CRT not only prevents clinical adverse events in 
      patients with mild CHF symptoms but also improves health status.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Versteeg, Henneke
AU  - Versteeg H
AD  - Center of Research on Psychology in Somatic diseases, Department of Medical 
      Psychology, Tilburg University, The Netherlands.
FAU - van den Broek, Krista C
AU  - van den Broek KC
FAU - Theuns, Dominic A M J
AU  - Theuns DA
FAU - Mommersteeg, Paula M C
AU  - Mommersteeg PM
FAU - Alings, Marco
AU  - Alings M
FAU - van der Voort, Pepijn H
AU  - van der Voort PH
FAU - Jordaens, Luc
AU  - Jordaens L
FAU - Pedersen, Susanne S
AU  - Pedersen SS
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20110806
PL  - United States
TA  - Am J Cardiol
JT  - The American journal of cardiology
JID - 0207277
SB  - IM
MH  - Cardiac Resynchronization Therapy/*methods
MH  - *Defibrillators, Implantable
MH  - Follow-Up Studies
MH  - *Health Status
MH  - Heart Failure/diagnosis/physiopathology/*therapy
MH  - Humans
MH  - Male
MH  - Prospective Studies
MH  - Severity of Illness Index
MH  - Stroke Volume/*physiology
MH  - Surveys and Questionnaires
MH  - Treatment Outcome
EDAT- 2011/08/09 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/08/09 06:00
PHST- 2011/04/26 00:00 [received]
PHST- 2011/06/06 00:00 [revised]
PHST- 2011/06/06 00:00 [accepted]
PHST- 2011/08/09 06:00 [entrez]
PHST- 2011/08/09 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - S0002-9149(11)02008-X [pii]
AID - 10.1016/j.amjcard.2011.06.019 [doi]
PST - ppublish
SO  - Am J Cardiol. 2011 Oct 15;108(8):1155-9. doi: 10.1016/j.amjcard.2011.06.019. Epub 
      2011 Aug 6.