PMID- 21821295
OWN - NLM
STAT- MEDLINE
DCOM- 20120125
LR  - 20191210
IS  - 1573-2517 (Electronic)
IS  - 0165-0327 (Linking)
VI  - 135
IP  - 1-3
DP  - 2011 Dec
TI  - Subjective recognition of adverse events with antidepressant in people with 
      depression: a prospective study.
PG  - 347-53
LID - 10.1016/j.jad.2011.07.011 [doi]
AB  - BACKGROUND: While it has been reported that physicians may under-recognize 
      adverse effects of antidepressants thoroughly in clinical settings, subjective 
      bias in recognition of adverse effects (AEs) with antidepressants has not been 
      specifically investigated. METHODS: Four-hundred ninety-three participants with 
      depressive disorders (ICD-10) were assessed for the severity of 20 common AEs and 
      their inferred causal relationship with antidepressants, together with the Quick 
      Inventory for Depressive Symptoms (QIDS). These assessments occurred twice at the 
      1st visit (when they were antidepressant free) and 2nd visit (10 days after the 
      initiation of antidepressants). 'Possible AEs' and 'under-recognized AEs' were 
      defined as 'events with exacerbation in the severity' and 'events with negative 
      causal attribution to antidepressants' at the time of the 2nd visit, 
      respectively. RESULTS: Three-hundred sixty-three participants (73.6%) experienced 
      >/= 1 under-recognized AEs. Flu like symptoms (96.5% of participants who 
      experienced possible AEs), sexual dysfunction (94.2%), blurred vision (93.4%), 
      anxiety/tension (91.1%) and sweating (89.2%) were found to be prevalent as 
      under-recognized AEs. Participants with under-recognized AEs had less improvement 
      in the QIDS than those without (27.1% vs. 11.1% decrease, p<0.001). LIMITATIONS: 
      It is intrinsically challenging to exactly differentiate between antidepressant 
      AEs and symptoms of depression. And the severity of depression, that of AEs and 
      causal relationship between AEs and antidepressants were assessed not by 
      objective but subjective scales. CONCLUSIONS: An overall trend to under-recognize 
      AEs of antidepressants was found and people with a lesser degree of early 
      improvement tend to understate the causality, which has an implication in 
      interpreting voluntarily expression of AEs.
CI  - Copyright (c) 2011 Elsevier B.V. All rights reserved.
FAU - Kikuchi, Toshiaki
AU  - Kikuchi T
AD  - Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan. 
      t-kick@nifty.com
FAU - Suzuki, Takefumi
AU  - Suzuki T
FAU - Uchida, Hiroyuki
AU  - Uchida H
FAU - Watanabe, Koichiro
AU  - Watanabe K
FAU - Kashima, Haruo
AU  - Kashima H
LA  - eng
PT  - Journal Article
DEP - 20110806
PL  - Netherlands
TA  - J Affect Disord
JT  - Journal of affective disorders
JID - 7906073
RN  - 0 (Antidepressive Agents)
SB  - IM
MH  - Adult
MH  - Antidepressive Agents/*adverse effects/therapeutic use
MH  - Causality
MH  - Depression
MH  - Depressive Disorder/*drug therapy
MH  - *Diagnostic Self Evaluation
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Personality Inventory
MH  - Prospective Studies
MH  - Recognition, Psychology
MH  - Severity of Illness Index
MH  - Young Adult
EDAT- 2011/08/09 06:00
MHDA- 2012/01/26 06:00
CRDT- 2011/08/09 06:00
PHST- 2010/12/31 00:00 [received]
PHST- 2011/07/14 00:00 [accepted]
PHST- 2011/08/09 06:00 [entrez]
PHST- 2011/08/09 06:00 [pubmed]
PHST- 2012/01/26 06:00 [medline]
AID - S0165-0327(11)00424-1 [pii]
AID - 10.1016/j.jad.2011.07.011 [doi]
PST - ppublish
SO  - J Affect Disord. 2011 Dec;135(1-3):347-53. doi: 10.1016/j.jad.2011.07.011. Epub 
      2011 Aug 6.