PMID- 218215
OWN - NLM
STAT- MEDLINE
DCOM- 19790523
LR  - 20190501
IS  - 0027-8424 (Print)
IS  - 1091-6490 (Electronic)
IS  - 0027-8424 (Linking)
VI  - 76
IP  - 2
DP  - 1979 Feb
TI  - Integration and transcription of mouse mammary tumor virus DNA in rat hepatoma 
      cells.
PG  - 665-9
AB  - Rat hepatoma cells infected with mouse mammary tumor virus (MMTV) acquire viral 
      DNA that becomes covalently linked to the cell DNA. Using restriction 
      endonucleases and the DNA transfer procedure of Southern [Southern , E.M. (1975) 
      J. Mol. Biol. 98, 503--517], we have studied the sites in cellular DNA into which 
      MMTV DNA inserts. These experiments indicate that: (i) there are many sites in 
      cell DNA into which MMTV DNA integrates; (ii) the junctions between viral and 
      cellular DNA occur within a limited portion of the viral genome, (iii) clones 
      that contain MMTV DNA do not necessarily produce viral RNA; and (iv) the extent 
      of transcription and glucocorticoid responsiveness of MMTV proviruses may be 
      dependent on the site(s) in cell DNA in which the viral DNA resides.
FAU - Ringold, G M
AU  - Ringold GM
FAU - Shank, P R
AU  - Shank PR
FAU - Varmus, H E
AU  - Varmus HE
FAU - Ring, J
AU  - Ring J
FAU - Yamamoto, K R
AU  - Yamamoto KR
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
RN  - 0 (DNA, Viral)
RN  - 0 (RNA, Viral)
SB  - IM
MH  - Animals
MH  - Base Sequence
MH  - Cell Line
MH  - Chromosome Mapping
MH  - DNA, Viral/*genetics
MH  - *Genes, Viral
MH  - Genetic Linkage
MH  - Liver Neoplasms, Experimental/*genetics
MH  - Mammary Tumor Virus, Mouse/*genetics
MH  - RNA, Viral/genetics
MH  - Rats
MH  - Recombination, Genetic
PMC - PMC383010
EDAT- 1979/02/01 00:00
MHDA- 1979/02/01 00:01
PMCR- 1979/08/01
CRDT- 1979/02/01 00:00
PHST- 1979/02/01 00:00 [pubmed]
PHST- 1979/02/01 00:01 [medline]
PHST- 1979/02/01 00:00 [entrez]
PHST- 1979/08/01 00:00 [pmc-release]
AID - 10.1073/pnas.76.2.665 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 1979 Feb;76(2):665-9. doi: 10.1073/pnas.76.2.665.