PMID- 21821500
OWN - NLM
STAT- MEDLINE
DCOM- 20120125
LR  - 20191210
IS  - 1308-0032 (Electronic)
IS  - 1302-8723 (Linking)
VI  - 11
IP  - 6
DP  - 2011 Sep
TI  - The effect of streptokinase therapy in STEMI and conventional therapy in NSTEMI 
      patients on TIMI risk index, B-type natriuretic peptide and high-sensitive 
      C-reactive protein.
PG  - 530-5
LID - 10.5152/akd.2011.138 [doi]
AB  - OBJECTIVE: In this study, it was aimed to investigate the effect of streptokinase 
      therapy in ST elevation myocardial infarction (STEMI) and conventional therapy in 
      non-ST elevation myocardial infarction (NSTEMI) patients on the thrombolysis in 
      myocardial infarction (TIMI) risk index (TRI), B-type natriuretic peptide (BNP), 
      and high-sensitive C-reactive protein (hs-CRP) levels. METHODS: Eighty-six STEMI 
      (male/female ratio: 65/21, mean age 57.52+/-9.87 years) and eighty NSTEMI patients 
      (male/female ratio: 50/30, mean age 57.6+/-1.7 years) were included in this 
      prospective observational study. Hs-CRP and BNP were measured and TIMI risk index 
      was calculated in all patients. Coronary angiography was performed in all 
      patients for principally determining TIMI flow rate. Chi-square test, paired 
      t-test or Wilcoxon signed rank test, ANOVA and Spearman correlation analysis were 
      used for statistical analysis where appropriate. RESULTS: STEMI patients had 
      higher systolic blood pressure, heart rate, BNP and hs-CRP values than NSTEMI 
      patients at admission (p=0.04, p=0.01, p=0.001 and p=0.01, respectively). 
      Thrombolytic therapy in STEMI patients resulted in statistically significant 
      higher levels of BNP, hs-CRP and TRI values compared to baseline levels (p=0.001, 
      p=0.001 and p=0.042, respectively). For NSTEMI patients conventional therapy 
      yielded statistically significant decrease in systolic blood pressure levels and 
      increase in TRI (p=0.001 and p=0.047, respectively). We found significantly lower 
      BNP, hs-CRP in patients with higher TIMI flow rate (p=0.001 and p=0.001 
      respectively). CONCLUSION: Thrombolytic therapy with streptokinase failed to 
      decrease BNP, hs-CRP and TRI values in STEMI patients. Conventional therapy in 
      NSTEMI patients also resulted in higher TRI values than baseline values. We 
      reached TIMI 3 flow in only 10.5% of the study patients, which may be responsible 
      for our findings.
FAU - Kurt, Ibrahim Halil
AU  - Kurt IH
AD  - Department of Cardiology, Adana Numune Education and Research Hospital, Turkey. 
      ibrahimhalilkurt@gmail.com
FAU - Batur, Mustafa Kemal
AU  - Batur MK
FAU - Unal, Ilker
AU  - Unal I
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
DEP - 20110808
PL  - Turkey
TA  - Anadolu Kardiyol Derg
JT  - Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology
JID - 101095069
RN  - 0 (Fibrinolytic Agents)
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - EC 3.4.- (Streptokinase)
SB  - IM
MH  - C-Reactive Protein/metabolism
MH  - Coronary Angiography
MH  - Female
MH  - Fibrinolytic Agents/administration & dosage/*therapeutic use
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/blood/diagnostic imaging/drug therapy/*therapy
MH  - Myocardial Reperfusion
MH  - Natriuretic Peptide, Brain/blood
MH  - Prospective Studies
MH  - Streptokinase/administration & dosage/*therapeutic use
MH  - Thrombolytic Therapy
MH  - Treatment Outcome
EDAT- 2011/08/09 06:00
MHDA- 2012/01/26 06:00
CRDT- 2011/08/09 06:00
PHST- 2011/08/09 06:00 [entrez]
PHST- 2011/08/09 06:00 [pubmed]
PHST- 2012/01/26 06:00 [medline]
AID - 10.5152/akd.2011.138 [doi]
PST - ppublish
SO  - Anadolu Kardiyol Derg. 2011 Sep;11(6):530-5. doi: 10.5152/akd.2011.138. Epub 2011 
      Aug 8.