PMID- 21823040
OWN - NLM
STAT- MEDLINE
DCOM- 20120424
LR  - 20211020
IS  - 1432-198X (Electronic)
IS  - 0931-041X (Linking)
VI  - 27
IP  - 2
DP  - 2012 Feb
TI  - High serum adiponectin concentration in children with chronic kidney disease.
PG  - 243-9
LID - 10.1007/s00467-011-1971-1 [doi]
AB  - Adiponectin (ADPN) counteracts the inflammatory response of the endothelium, 
      which plays an important role in the development of atherosclerosis in patients 
      with chronic kidney disease (CKD). Data in children with CKD are scarce. We 
      examined serum ADPN concentration in 90 children with various renal disorders: 28 
      with CKD on conservative treatment (CKD), 21 on regular dialysis treatment (D), 
      and 41 after kidney transplantation (Tx); 27 age-matched healthy children served 
      as controls (C). Body mass index (BMI), estimated glomerular filtration rate 
      (eGFR), lipids, homocysteine, high sensitivity CRP (hsCRP), and systolic blood 
      pressure (SBP) were also measured. Mean serum ADPN concentration was 
      significantly higher in patients with CKD (27.3 mug/ml +/-15.0), on D (34.2 mug/ml 
      +/-14.9), and after Tx (23.6 mug/ml +/-9.5) compared with ADPN levels in C (13.5 mug/ml 
      +/-6.1) (p < 0.0001). Serum ADPN concentration was inversely related to BMI 
      (p = 0.001) and SBP (p = 0.004). In the multiple linear regression analysis, only 
      SBP remained independently associated with ADPN plasma levels. Data show that 
      children with CKD have significantly higher serum ADPN, even after Tx. The 
      protective antiarthrosclerotic effect of ADPN may be mediated by lower SBP, a 
      finding that deserves further study.
FAU - Moller, Kristina F
AU  - Moller KF
AD  - Pediatric Nephrology, Klinik fur Kinder- und Jugendmedizin, Universitatsklinikum 
      Hamburg Eppendorf, Martinistr. 52, 20246, Hamburg, Germany. 
      zepf@uke.uni-hamburg.de
FAU - Dieterman, Christina
AU  - Dieterman C
FAU - Herich, Lena
AU  - Herich L
FAU - Klaassen, Ilka A
AU  - Klaassen IA
FAU - Kemper, Markus J
AU  - Kemper MJ
FAU - Muller-Wiefel, Dirk E
AU  - Muller-Wiefel DE
LA  - eng
PT  - Journal Article
DEP - 20110809
PL  - Germany
TA  - Pediatr Nephrol
JT  - Pediatric nephrology (Berlin, Germany)
JID - 8708728
RN  - 0 (Adiponectin)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Adiponectin/*blood
MH  - Adolescent
MH  - Body Mass Index
MH  - C-Reactive Protein/analysis
MH  - Child
MH  - Child, Preschool
MH  - Chronic Disease
MH  - Female
MH  - Glomerular Filtration Rate
MH  - Humans
MH  - Kidney Diseases/*blood/physiopathology
MH  - Male
MH  - Systole
EDAT- 2011/08/09 06:00
MHDA- 2012/04/25 06:00
CRDT- 2011/08/09 06:00
PHST- 2011/01/12 00:00 [received]
PHST- 2011/06/27 00:00 [accepted]
PHST- 2011/06/22 00:00 [revised]
PHST- 2011/08/09 06:00 [entrez]
PHST- 2011/08/09 06:00 [pubmed]
PHST- 2012/04/25 06:00 [medline]
AID - 10.1007/s00467-011-1971-1 [doi]
PST - ppublish
SO  - Pediatr Nephrol. 2012 Feb;27(2):243-9. doi: 10.1007/s00467-011-1971-1. Epub 2011 
      Aug 9.