PMID- 21823139
OWN - NLM
STAT- MEDLINE
DCOM- 20111212
LR  - 20220309
IS  - 1098-108X (Electronic)
IS  - 0276-3478 (Linking)
VI  - 44
IP  - 6
DP  - 2011 Sep
TI  - Changes of orexin A plasma levels in girls with anorexia nervosa during eight 
      weeks of realimentation.
PG  - 547-52
LID - 10.1002/eat.20857 [doi]
AB  - OBJECTIVE: Orexin A (OXA) is a hypothalamic neuropeptide involved in regulation 
      of food intake and nutritional status. There are multiple disturbances of 
      neuropeptide signaling described in girls with anorexia nervosa (AN), but OXA 
      levels have not been addressed in this population to date. Therefore, we analyzed 
      OXA levels of AN girls in this study. METHOD: OXA (radioimmunoassay/RIA/method), 
      leptin, insulinlike growth factor-1 (IGF-1), and insulinlike growth factor-1 
      binding protein-3 (IGFBP-3) levels were measured before and after 8 weeks of 
      realimentation in 36 girls with AN and in 14 healthy controls (control group: 
      CG). RESULTS: Average weight increased significantly in AN during the study (p < 
      .0001), while plasma levels of OXA decreased (before realimentation: 56.2 +/- 2.4 
      pg/ml; after realimentation: 47.5 +/- 1.4 pg/ml; p = .0025). OXA levels before 
      realimentation differed from levels in the CG (47.15 +/- 2.6 pg/ml, p = .034), but 
      not afterward. We did not find any correlation between OXA and age, height, 
      weight, BMI; or IGF-1, IGFBP-3, and leptin levels. DISCUSSION: OXA levels in 
      untreated AN patients differ significantly from healthy subjects and decrease 
      during realimentation. These findings indicate that OXA may be involved in the 
      nutritional regulation of malnourished children and adolescents.
CI  - Copyright (c) 2010 Wiley Periodicals, Inc.
FAU - Bronsky, Jiri
AU  - Bronsky J
AD  - Department of Pediatrics, Second Medical Faculty, Charles University and 
      University Hospital Motol, Prague, Czech Republic. bronsky@email.cz
FAU - Nedvidkova, Jara
AU  - Nedvidkova J
FAU - Krasnicanova, Hana
AU  - Krasnicanova H
FAU - Vesela, Marie
AU  - Vesela M
FAU - Schmidtova, Jana
AU  - Schmidtova J
FAU - Koutek, Jiri
AU  - Koutek J
FAU - Kellermayer, Richard
AU  - Kellermayer R
FAU - Chada, Martin
AU  - Chada M
FAU - Kabelka, Zdenek
AU  - Kabelka Z
FAU - Hrdlicka, Michal
AU  - Hrdlicka M
FAU - Nevoral, Jiri
AU  - Nevoral J
FAU - Prusa, Richard
AU  - Prusa R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101026
PL  - United States
TA  - Int J Eat Disord
JT  - The International journal of eating disorders
JID - 8111226
RN  - 0 (HCRT protein, human)
RN  - 0 (Insulin-Like Growth Factor Binding Protein 3)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (Leptin)
RN  - 0 (Neuropeptides)
RN  - 0 (Orexins)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
SB  - IM
MH  - Adolescent
MH  - Anorexia Nervosa/*blood/therapy
MH  - Body Weight/*physiology
MH  - Eating/physiology
MH  - Female
MH  - Humans
MH  - Insulin-Like Growth Factor Binding Protein 3/blood
MH  - Insulin-Like Growth Factor I/metabolism
MH  - Intracellular Signaling Peptides and Proteins/*blood
MH  - Leptin/blood
MH  - Neuropeptides/*blood
MH  - Nutritional Status
MH  - Orexins
EDAT- 2011/08/09 06:00
MHDA- 2011/12/14 06:00
CRDT- 2011/08/09 06:00
PHST- 2010/06/27 00:00 [accepted]
PHST- 2011/08/09 06:00 [entrez]
PHST- 2011/08/09 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
AID - 10.1002/eat.20857 [doi]
PST - ppublish
SO  - Int J Eat Disord. 2011 Sep;44(6):547-52. doi: 10.1002/eat.20857. Epub 2010 Oct 
      26.