PMID- 21823462
OWN - NLM
STAT- MEDLINE
DCOM- 20120123
LR  - 20131121
IS  - 1001-4454 (Print)
IS  - 1001-4454 (Linking)
VI  - 34
IP  - 3
DP  - 2011 Mar
TI  - [Study on the ultraviolet protective effects of the cream of the total flavonoids 
      from Oxytropis falcata].
PG  - 415-20
AB  - OBJECTIVE: To study the protective effects of the cream of the total flavonoids 
      from Oxytropis falcata on the destructed skin of mice induced by moderate-wave 
      ultraviolet (UVB) irradiation. METHODS: Dorsal skin of Wistar mice were treated 
      with the cream of the total flavonoids from Oxytropis falcata and then irradiated 
      with UVB in the dosage of 5 min once a day for one week. The tissue of skin was 
      pathological diagnosed and the activities or contents of superoxide dismutase 
      (SOD), malondialdehyde (MDA), hydroxyproline (Hyp), glutathione peroxidease 
      (GSH-Px), glutathione (GSH), glutathion-s-transferase (GST), catalase (CAT) and 
      hydroxy radical (*OH) were determined with chromatometry. RESULTS: The 
      ultraviolet protective effects of the cream could be observed with appearance and 
      pathology examine. The cream could increase the activities of SOD (P < 0.001), 
      GSH-Px (P < 0.001), GST (P < 0.05) and CAT (P < 0.01), raise the content of Hyp 
      (P < 0.001) significantly. The cream could also decrease the contents of MDA and 
      *OH (P < 0.001), and the activities of GSH significantly (P < 0.001). CONCLUSION: 
      The cream of the total flavonoids from Oxytropis falcata has protective effect on 
      the destructed skin of mice induced by moderate-wave ultraviolet (UVB) 
      irradiation.
FAU - Li, Mao-Xing
AU  - Li MX
AD  - Department of Pharmacy, Lanzhou General Hospital of PLA, Lanzhou 730050, China. 
      lm730530xing@yahoo.com.cn
FAU - Lan, Zhi-Hui
AU  - Lan ZH
FAU - He, Xi-Rui
AU  - He XR
FAU - Zhang, Ru-Xue
AU  - Zhang RX
FAU - Jia, Zheng-Ping
AU  - Jia ZP
FAU - Du, Qing-Yun
AU  - Du QY
FAU - Hong, Jia-Ni
AU  - Hong JN
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhong Yao Cai
JT  - Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials
JID - 9426370
RN  - 0 (Antioxidants)
RN  - 0 (Flavonoids)
RN  - 0 (Radiation-Protective Agents)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - BBX060AN9V (Hydrogen Peroxide)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - EC 2.5.1.18 (Glutathione Transferase)
SB  - IM
MH  - Animals
MH  - Antioxidants/administration & dosage/*pharmacology
MH  - Body Weight/drug effects
MH  - Disease Models, Animal
MH  - Female
MH  - Flavonoids/*pharmacology
MH  - Glutathione Peroxidase/metabolism
MH  - Glutathione Transferase/metabolism
MH  - Hydrogen Peroxide/metabolism
MH  - Malondialdehyde/metabolism
MH  - Oxidative Stress
MH  - Oxytropis/chemistry
MH  - Radiation-Protective Agents/*pharmacology
MH  - Random Allocation
MH  - Rats
MH  - Rats, Wistar
MH  - Skin/*drug effects/metabolism/pathology/*radiation effects
MH  - Superoxide Dismutase/metabolism
MH  - Ultraviolet Rays/*adverse effects
EDAT- 2011/08/10 06:00
MHDA- 2012/01/24 06:00
CRDT- 2011/08/10 06:00
PHST- 2011/08/10 06:00 [entrez]
PHST- 2011/08/10 06:00 [pubmed]
PHST- 2012/01/24 06:00 [medline]
PST - ppublish
SO  - Zhong Yao Cai. 2011 Mar;34(3):415-20.