PMID- 21823610
OWN - NLM
STAT- MEDLINE
DCOM- 20120113
LR  - 20121115
IS  - 1520-5827 (Electronic)
IS  - 0743-7463 (Linking)
VI  - 27
IP  - 18
DP  - 2011 Sep 20
TI  - Deactivation efficiency of stabilized bactericidal emulsions.
PG  - 11296-305
LID - 10.1021/la201112j [doi]
AB  - Biocide emulsions stabilized with various stabilizing agents were prepared and 
      characterized, and their efficiency in bacteria deactivation was evaluated. A 
      number of stabilizing agents were tested for their stabilizing effect on 
      emulsions of thiocyanomethylthiobenzothiazole (TCMTB) biocide. Two agents, the 
      most successful in stabilizing the biocide, were chosen for further studies: high 
      molecular weight polyethyleneimine (PEI) and an amphiphilic block copolymer of 
      poly(caprolactone)-b-poly(acrylic acid) (PCL(33)-b-PAA(33)). The emulsion droplet 
      sizes varied between 325 and 500 nm. Deactivation of bacteria was studied by 
      exposing E. coli ATCC 11229 bacteria dispersions to emulsions stabilized by 
      positively charged PEI or negatively charged PCL-b-PAA micelles and by measuring 
      their absorbance; E. coli do not grow with time in the presence of biocide 
      emulsions. PEI molecules alone act as biocide and deactivate the bacteria. 
      PCL-b-PAA micelles as stabilizing agent do not affect the growth of the E. coli ; 
      bacteria are deactivated by TCMTB released from the emulsion droplets. The 
      kinetics of emulsion dissolution studies revealed for both stabilizing agents a 
      decrease in droplet size with time while the emulsions were subjected to 
      dialysis. The biocide was released from the emulsions within  approximately 250 min; the 
      droplet shells consist mostly of PEI or PCL-b-PAA insoluble complexes with the 
      biocide, which do not dissolve during dialysis. SEM images confirm the presence 
      of residual crumbled shells with holes after 24 h of dialysis.
CI  - (c) 2011 American Chemical Society
FAU - Vyhnalkova, Renata
AU  - Vyhnalkova R
AD  - Pulp and Paper Research Centre, McGill University, 3420 University Street, 
      Montreal, Quebec H3A 2A7, Canada.
FAU - Eisenberg, Adi
AU  - Eisenberg A
FAU - van de Ven, Theo G M
AU  - van de Ven TG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110822
PL  - United States
TA  - Langmuir
JT  - Langmuir : the ACS journal of surfaces and colloids
JID - 9882736
RN  - 0 (Benzothiazoles)
RN  - 0 (Disinfectants)
RN  - 0 (Emulsions)
RN  - 0 (Micelles)
RN  - 0 (Polymers)
RN  - 0 (Thiocyanates)
RN  - 5GE166YVQV (2-(thiocyanomethylthio)benzothiazole)
SB  - IM
MH  - Benzothiazoles/*chemistry/*pharmacology
MH  - Disinfectants/*chemistry/*pharmacology
MH  - Emulsions
MH  - Escherichia coli/drug effects
MH  - Hydrophobic and Hydrophilic Interactions
MH  - Kinetics
MH  - Micelles
MH  - Microbial Viability/*drug effects
MH  - Polymers/chemistry
MH  - Thiocyanates/*chemistry/*pharmacology
EDAT- 2011/08/10 06:00
MHDA- 2012/01/14 06:00
CRDT- 2011/08/10 06:00
PHST- 2011/08/10 06:00 [entrez]
PHST- 2011/08/10 06:00 [pubmed]
PHST- 2012/01/14 06:00 [medline]
AID - 10.1021/la201112j [doi]
PST - ppublish
SO  - Langmuir. 2011 Sep 20;27(18):11296-305. doi: 10.1021/la201112j. Epub 2011 Aug 22.