PMID- 21826275
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 2090-4444 (Electronic)
IS  - 2090-4436 (Print)
IS  - 2090-4436 (Linking)
VI  - 2011
DP  - 2011
TI  - Carcinomas of Distal Fallopian Tube and Their Association with Tubal 
      Intraepithelial Carcinoma: Do They Share a Common "Precursor" Lesion? Loss of 
      Heterozygosity and Immunohistochemical Analysis Using PAX 2, WT-1, and P53 
      Markers.
PG  - 858647
LID - 10.5402/2011/858647 [doi]
LID - 858647
AB  - As the role of distal fallopian tube as organ of serous carcinogenesis is 
      emerging, additional literature on the role of tubal intraepithelial carcinoma 
      (TIC) as a precursor lesion in a subset of primary peritoneal serous carcinomas 
      (PPSC is emerging as well. TIC although fallopian tube in origin can be 
      genetically related to ovarian/peritoneal carcinomas. The role of PAX2 in primary 
      fallopian tube carcinomas (PFTC)/PPSC is yet to be defined. The aim of our study 
      was to understand if the biologic properties of tumors arising in the distal 
      fallopian tube that remain as PFTC are different when they seed on to the 
      peritoneal surface (PPSC). A panel of 6 polymorphic microsatellite markers 
      corresponding to p53, PAX2, and WT1 tumor suppressor genes were studied. Invasive 
      carcinomas as well as TIC arising in the distal fallopian tube when remain as 
      PFTC appears to exhibit different LOH patterns in comparison to PPSC. PAX 2 LOH 
      patterns might represent a "hidden PAX 2 signature" analogous to p53 signatures. 
      PAX 2 might be an emerging marker for detection of early serous carcinomas 
      particularly in BRCA + women.
FAU - Chivukula, Mamatha
AU  - Chivukula M
AD  - Department of Pathology, Magee Womens Hospital of UPMC, 300 Halket Street, 
      Pittsburgh, PA 15213, USA.
FAU - Niemeier, Leo A
AU  - Niemeier LA
FAU - Edwards, Robert
AU  - Edwards R
FAU - Nikiforova, Marina
AU  - Nikiforova M
FAU - Mantha, Geetha
AU  - Mantha G
FAU - McManus, Kim
AU  - McManus K
FAU - Carter, Gloria
AU  - Carter G
LA  - eng
PT  - Journal Article
DEP - 20101215
PL  - United States
TA  - ISRN Obstet Gynecol
JT  - ISRN obstetrics and gynecology
JID - 101558763
PMC - PMC3149410
EDAT- 2011/08/10 06:00
MHDA- 2011/08/10 06:01
PMCR- 2010/12/15
CRDT- 2011/08/10 06:00
PHST- 2010/09/22 00:00 [received]
PHST- 2010/10/19 00:00 [accepted]
PHST- 2011/08/10 06:00 [entrez]
PHST- 2011/08/10 06:00 [pubmed]
PHST- 2011/08/10 06:01 [medline]
PHST- 2010/12/15 00:00 [pmc-release]
AID - 10.5402/2011/858647 [doi]
PST - ppublish
SO  - ISRN Obstet Gynecol. 2011;2011:858647. doi: 10.5402/2011/858647. Epub 2010 Dec 
      15.