PMID- 21827409
OWN - NLM
STAT- MEDLINE
DCOM- 20120322
LR  - 20190728
IS  - 1873-4286 (Electronic)
IS  - 1381-6128 (Linking)
VI  - 17
IP  - 26
DP  - 2011
TI  - Getting to know the cast - cellular interactions and signaling at the 
      neurovascular unit.
PG  - 2750-4
AB  - The neurovascular unit (NVU), consisting of endothelial cells, basement membrane, 
      pericytes, astrocytes and microglial cells, couples local neuronal function to 
      local cerebral blood flow and regulates transport of blood-borne molecules across 
      the blood-brain barrier (BBB). The building blocks and the phenotype of the NVU 
      are well-established but the intercellular signaling between the different 
      components remains elusive. A better understanding of the cellular interactions 
      and signaling within the NVU is critical for the development of efficient 
      therapeutics for the treatment of a variety of brain diseases, such as brain 
      cancer, stroke, neuroinflammation and neurodegeneration. This review gives an 
      overview about the current in vivo knowledge of the NVU and the communication 
      between its different cellular constituents. We also discuss the usefulness of 
      various model organisms for studies of the brain vasculature.
FAU - Mae, Maarja
AU  - Mae M
AD  - Division of Vascular Biology, Department of Medical Biochemistry and Biophysics, 
      Karolinska Institute, SE-171 77, Stockholm, Sweden. Maarja.Mae@ki.se
FAU - Armulik, Annika
AU  - Armulik A
FAU - Betsholtz, Christer
AU  - Betsholtz C
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United Arab Emirates
TA  - Curr Pharm Des
JT  - Current pharmaceutical design
JID - 9602487
SB  - IM
MH  - Animals
MH  - Biological Transport
MH  - Blood-Brain Barrier/metabolism
MH  - Brain/*metabolism/physiopathology
MH  - Brain Diseases/drug therapy/*physiopathology
MH  - Cell Communication
MH  - *Drug Design
MH  - Humans
MH  - Signal Transduction/physiology
EDAT- 2011/08/11 06:00
MHDA- 2012/03/23 06:00
CRDT- 2011/08/11 06:00
PHST- 2011/06/28 00:00 [received]
PHST- 2011/07/07 00:00 [accepted]
PHST- 2011/08/11 06:00 [entrez]
PHST- 2011/08/11 06:00 [pubmed]
PHST- 2012/03/23 06:00 [medline]
AID - BSP/CPD/E-Pub/000560 [pii]
AID - 10.2174/138161211797440113 [doi]
PST - ppublish
SO  - Curr Pharm Des. 2011;17(26):2750-4. doi: 10.2174/138161211797440113.