PMID- 21829393
OWN - NLM
STAT- MEDLINE
DCOM- 20111209
LR  - 20220311
IS  - 1553-7404 (Electronic)
IS  - 1553-7390 (Print)
IS  - 1553-7390 (Linking)
VI  - 7
IP  - 8
DP  - 2011 Aug
TI  - Genome-wide association analysis of autoantibody positivity in type 1 diabetes 
      cases.
PG  - e1002216
LID - 10.1371/journal.pgen.1002216 [doi]
LID - e1002216
AB  - The genetic basis of autoantibody production is largely unknown outside of 
      associations located in the major histocompatibility complex (MHC) human 
      leukocyte antigen (HLA) region. The aim of this study is the discovery of new 
      genetic associations with autoantibody positivity using genome-wide association 
      scan single nucleotide polymorphism (SNP) data in type 1 diabetes (T1D) patients 
      with autoantibody measurements. We measured two anti-islet autoantibodies, 
      glutamate decarboxylase (GADA, n = 2,506), insulinoma-associated antigen 2 
      (IA-2A, n = 2,498), antibodies to the autoimmune thyroid (Graves') disease (AITD) 
      autoantigen thyroid peroxidase (TPOA, n = 8,300), and antibodies against gastric 
      parietal cells (PCA, n = 4,328) that are associated with autoimmune gastritis. 
      Two loci passed a stringent genome-wide significance level (p<10(-10)): 
      1q23/FCRL3 with IA-2A and 9q34/ABO with PCA. Eleven of 52 non-MHC T1D loci showed 
      evidence of association with at least one autoantibody at a false discovery rate 
      of 16%: 16p11/IL27-IA-2A, 2q24/IFIH1-IA-2A and PCA, 2q32/STAT4-TPOA, 
      10p15/IL2RA-GADA, 6q15/BACH2-TPOA, 21q22/UBASH3A-TPOA, 1p13/PTPN22-TPOA, 
      2q33/CTLA4-TPOA, 4q27/IL2/TPOA, 15q14/RASGRP1/TPOA, and 12q24/SH2B3-GADA and 
      TPOA. Analysis of the TPOA-associated loci in 2,477 cases with Graves' disease 
      identified two new AITD loci (BACH2 and UBASH3A).
FAU - Plagnol, Vincent
AU  - Plagnol V
AD  - Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation 
      Laboratory, Department of Medical Genetics, Cambridge Institute for Medical 
      Research, National Institute for Health Research Biomedical Research Centre, 
      University of Cambridge, Cambridge, United Kingdom. v.plagnol@ucl.ac.uk
FAU - Howson, Joanna M M
AU  - Howson JM
FAU - Smyth, Deborah J
AU  - Smyth DJ
FAU - Walker, Neil
AU  - Walker N
FAU - Hafler, Jason P
AU  - Hafler JP
FAU - Wallace, Chris
AU  - Wallace C
FAU - Stevens, Helen
AU  - Stevens H
FAU - Jackson, Laura
AU  - Jackson L
FAU - Simmonds, Matthew J
AU  - Simmonds MJ
CN  - Type 1 Diabetes Genetics Consortium
FAU - Bingley, Polly J
AU  - Bingley PJ
FAU - Gough, Stephen C
AU  - Gough SC
FAU - Todd, John A
AU  - Todd JA
LA  - eng
GR  - 079895/WT_/Wellcome Trust/United Kingdom
GR  - 089989/WT_/Wellcome Trust/United Kingdom
GR  - RG/08/014/24067/BHF_/British Heart Foundation/United Kingdom
GR  - 091157/WT_/Wellcome Trust/United Kingdom
GR  - RG52731/RG/CSR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20110804
PL  - United States
TA  - PLoS Genet
JT  - PLoS genetics
JID - 101239074
RN  - 0 (ABO Blood-Group System)
RN  - 0 (Autoantibodies)
RN  - 0 (FCRL1 protein, human)
RN  - 0 (FCRL3 protein, human)
RN  - 0 (Membrane Proteins)
RN  - 0 (Receptors, Immunologic)
SB  - IM
MH  - ABO Blood-Group System/genetics
MH  - Adolescent
MH  - Autoantibodies/*genetics/*immunology
MH  - Child
MH  - Child, Preschool
MH  - Chromosomes, Human, Pair 1/genetics
MH  - Chromosomes, Human, Pair 9/genetics
MH  - Diabetes Mellitus, Type 1/*genetics/*immunology
MH  - *Genome-Wide Association Study
MH  - Graves Disease/genetics/immunology
MH  - Humans
MH  - Membrane Proteins/genetics
MH  - Polymorphism, Single Nucleotide/genetics
MH  - Receptors, Immunologic/genetics
PMC - PMC3150451
COIS- The authors have declared that no competing interests exist.
EDAT- 2011/08/11 06:00
MHDA- 2011/12/14 06:00
PMCR- 2011/08/01
CRDT- 2011/08/11 06:00
PHST- 2011/02/08 00:00 [received]
PHST- 2011/06/17 00:00 [accepted]
PHST- 2011/08/11 06:00 [entrez]
PHST- 2011/08/11 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
PHST- 2011/08/01 00:00 [pmc-release]
AID - PGENETICS-D-11-00277 [pii]
AID - 10.1371/journal.pgen.1002216 [doi]
PST - ppublish
SO  - PLoS Genet. 2011 Aug;7(8):e1002216. doi: 10.1371/journal.pgen.1002216. Epub 2011 
      Aug 4.