PMID- 2182973
OWN - NLM
STAT- MEDLINE
DCOM- 19900515
LR  - 20190725
IS  - 0026-0495 (Print)
IS  - 0026-0495 (Linking)
VI  - 39
IP  - 4
DP  - 1990 Apr
TI  - Aspartame ingestion with and without carbohydrate in phenylketonuric and normal 
      subjects: effect on plasma concentrations of amino acids, glucose, and insulin.
PG  - 391-6
AB  - Seven subjects homozygous for phenylketonuria (PKU) and seven normal subjects 
      were administered four beverage regimens after an overnight fast: unsweetened 
      beverage, beverage providing carbohydrate (CHO), beverage providing aspartame 
      (APM), and beverage providing APM plus CHO. The APM dose (200 mg) was the amount 
      provided in 12 oz of diet beverage; the CHO was partially hydrolyzed starch (60 
      g). Plasma amino acid concentrations were determined after dosing and the molar 
      plasma phenylalanine (Phe) to large neutral amino acid (LNAA) ratio calculated. 
      APM administration without CHO did not increase plasma Phe concentrations over 
      baseline values in either normal or PKU subjects (5.48 +/- 0.85 and 150 +/- 23.0 
      mumols/dL, respectively). Similarly, the Phe/LNAA did not increase significantly. 
      Ingestion of beverage providing APM and CHO did not significantly increase plasma 
      Phe concentrations over baseline values in either normal or PKU subjects. 
      However, ingestion of beverage providing CHO (with or without APM) significantly 
      decreased plasma levels of valine, isoleucine, and leucine 1.5 to 4 hours after 
      dosing in both normal and PKU subjects, thereby increasing the Phe/LNAA ratio 
      significantly. These data indicate that changes noted in Phe/LNAA values after 
      ingestion of beverage providing APM plus CHO were due to CHO. The plasma insulin 
      response to beverage providing CHO (with or without APM) was significantly higher 
      in PKU subjects than in normals.
FAU - Wolf-Novak, L C
AU  - Wolf-Novak LC
AD  - Department of Pediatrics, University of Iowa College of Medicine, Iowa City.
FAU - Stegink, L D
AU  - Stegink LD
FAU - Brummel, M C
AU  - Brummel MC
FAU - Persoon, T J
AU  - Persoon TJ
FAU - Filer, L J Jr
AU  - Filer LJ Jr
FAU - Bell, E F
AU  - Bell EF
FAU - Ziegler, E E
AU  - Ziegler EE
FAU - Krause, W L
AU  - Krause WL
LA  - eng
GR  - RR59/RR/NCRR NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Metabolism
JT  - Metabolism: clinical and experimental
JID - 0375267
RN  - 0 (Amino Acids)
RN  - 0 (Blood Glucose)
RN  - 0 (Dipeptides)
RN  - 0 (Insulin)
RN  - Z0H242BBR1 (Aspartame)
SB  - IM
MH  - Adolescent
MH  - Amino Acids/*blood
MH  - Aspartame/administration & dosage/*pharmacology
MH  - Beverages
MH  - Blood Glucose/*metabolism
MH  - Diet
MH  - Dipeptides/*pharmacology
MH  - Female
MH  - Humans
MH  - Insulin/*blood
MH  - Kinetics
MH  - Male
MH  - Phenylketonurias/*blood
MH  - Reference Values
MH  - Time Factors
EDAT- 1990/04/01 00:00
MHDA- 2001/03/28 10:01
CRDT- 1990/04/01 00:00
PHST- 1990/04/01 00:00 [pubmed]
PHST- 2001/03/28 10:01 [medline]
PHST- 1990/04/01 00:00 [entrez]
AID - 0026-0495(90)90254-A [pii]
AID - 10.1016/0026-0495(90)90254-a [doi]
PST - ppublish
SO  - Metabolism. 1990 Apr;39(4):391-6. doi: 10.1016/0026-0495(90)90254-a.