PMID- 21830182
OWN - NLM
STAT- MEDLINE
DCOM- 20111024
LR  - 20151119
IS  - 1438-9010 (Electronic)
IS  - 1438-9010 (Linking)
VI  - 183
IP  - 9
DP  - 2011 Sep
TI  - New insights into peripartum cardiomyopathy using cardiac magnetic resonance 
      imaging.
PG  - 834-41
LID - 10.1055/s-0031-1281600 [doi]
AB  - PURPOSE: The aim of this study was to evaluate a comprehensive cardiac magnetic 
      resonance (MR) imaging approach in patients with peripartum cardiomyopathy 
      (PPCM). The focus was on inflammatory myocardial changes. MATERIALS AND METHODS: 
      Retrospective analysis of 12 cardiac MR examinations was performed in 6 patients 
      with PPCM. The protocol comprised cine sequences for the determination of chamber 
      sizes and function. T 2-weighted sequences for determination of edema (T 2 
      ratio), T 1-weighted images for measurement of early gadolinium enhancement ratio 
      (EGER), and late gadolinium enhancement (LGE) sequences were used for tissue 
      characterization. 5 examinations were performed during the acute stage, and 7 
      examinations were performed during the course of the disease. RESULTS: Initially, 
      3 of 5 patients presented with an elevated left ventricular end-diastolic volume 
      (LVEDV); in one patient, the LVEDV was in the upper range. In 4 of 5 subjects, 
      the left ventricular ejection fraction (LVEF) was decreased. The T 2 ratio and 
      EGER values were initially elevated in all women. No LGE was detected in initial 
      scans. In follow-up examinations, the LVEDV decreased and the LVEF increased in 
      all patients. Tissue-characterizing parameters decreased to normal in all but 1 
      patient. 2 patients showing LGE did not present a favorable clinical course. 
      CONCLUSION: Myocardial inflammation was detected in the acute stage of PPCM, 
      which was mostly transient. In our small group, patients showing LGE had a 
      non-favorable clinical course. Future studies should include 
      tissue-characterizing parameters, such as T 2 ratio and EGER. Thus, further 
      insights into pathophysiology can be gained and therapeutic effects can be 
      measured in a more extensive manner.
CI  - (c) Georg Thieme Verlag KG Stuttgart . New York.
FAU - Renz, D M
AU  - Renz DM
AD  - Institut fur Radiologie, Charite Universitatsmedizin Berlin, Germany.
FAU - Rottgen, R
AU  - Rottgen R
FAU - Habedank, D
AU  - Habedank D
FAU - Wagner, M
AU  - Wagner M
FAU - Bottcher, J
AU  - Bottcher J
FAU - Pfeil, A
AU  - Pfeil A
FAU - Dietz, R
AU  - Dietz R
FAU - Kivelitz, D
AU  - Kivelitz D
FAU - Elgeti, T
AU  - Elgeti T
LA  - eng
PT  - Journal Article
DEP - 20110809
PL  - Germany
TA  - Rofo
JT  - RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin
JID - 7507497
RN  - 0 (Contrast Media)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
MH  - Acute Disease
MH  - Adult
MH  - Cardiomyopathies/*diagnosis
MH  - Contrast Media/administration & dosage
MH  - Female
MH  - Follow-Up Studies
MH  - Gadolinium DTPA
MH  - Heart Atria/pathology
MH  - Heart Failure/diagnosis
MH  - Heart Ventricles/pathology
MH  - Humans
MH  - Hypertrophy, Left Ventricular/diagnosis
MH  - Image Enhancement/*methods
MH  - Image Processing, Computer-Assisted/*methods
MH  - Magnetic Resonance Imaging/*methods
MH  - Magnetic Resonance Imaging, Cine/*methods
MH  - Myocardium/pathology
MH  - Peripartum Period
MH  - Pregnancy
MH  - Pregnancy Complications, Cardiovascular/*diagnosis
MH  - Puerperal Disorders/*diagnosis
MH  - Reference Values
MH  - Retrospective Studies
MH  - Stroke Volume/physiology
MH  - Young Adult
EDAT- 2011/08/11 06:00
MHDA- 2011/10/25 06:00
CRDT- 2011/08/11 06:00
PHST- 2011/08/11 06:00 [entrez]
PHST- 2011/08/11 06:00 [pubmed]
PHST- 2011/10/25 06:00 [medline]
AID - 10.1055/s-0031-1281600 [doi]
PST - ppublish
SO  - Rofo. 2011 Sep;183(9):834-41. doi: 10.1055/s-0031-1281600. Epub 2011 Aug 9.