PMID- 21830746
OWN - NLM
STAT- MEDLINE
DCOM- 20120106
LR  - 20131121
IS  - 1938-2375 (Electronic)
IS  - 1542-8877 (Linking)
VI  - 42
IP  - 6
DP  - 2011 Nov-Dec
TI  - Spectral-domain optical coherence tomography as a screening technique for 
      chloroquine and hydroxychloroquine retinal toxicity.
PG  - 493-7
LID - 10.3928/15428877-20110804-02 [doi]
AB  - BACKGROUND AND OBJECTIVE: To determine the effectiveness of spectral-domain 
      optical coherence tomography (SD-OCT) as a screening tool for the evaluation of 
      chloroquine or hydroxychloroquine retinal toxicity. PATIENTS AND METHODS: This is 
      a prospective, case-control study. Subject eyes were divided into four groups 
      (group I = eyes with bull's eye maculopathy, group II = eyes with early changes 
      of toxicity, group III = eyes with exposure but no signs of toxicity, and group 
      IV = eyes of age-matched controls). Retinal thickness was measured via SD-OCT 0.5 
      and 1.0 mm from the foveal center. RESULTS: Mean retinal thickness 1.0 mm from 
      the fovea in group I eyes was significantly thinner when compared to group IV. 
      Eyes in group II also showed retinal thinning 1.0 mm from the foveal center when 
      compared to both groups III and IV. Mean retinal thickness 0.5 mm from the foveal 
      center did not differ significantly between any groups. CONCLUSION: Significant 
      retinal thinning occurred 1.0 mm, but not 0.5 mm, from the foveal center in 
      patients with early and late chloroquine or hydroxychloroquine toxicity. 
      Measuring retinal thickness 1.0 mm from the foveal center in patients receiving 
      these medications may help screen for early toxicity.
CI  - Copyright 2011, SLACK Incorporated.
FAU - Kahn, Jonathan B
AU  - Kahn JB
AD  - Department of Ophthalmology, New York University School of Medicine, New York, NY 
      10016, USA.
FAU - Haberman, Ilyse D
AU  - Haberman ID
FAU - Reddy, Shantan
AU  - Reddy S
LA  - eng
PT  - Journal Article
DEP - 20110811
PL  - United States
TA  - Ophthalmic Surg Lasers Imaging
JT  - Ophthalmic surgery, lasers & imaging : the official journal of the International 
      Society for Imaging in the Eye
JID - 101155780
RN  - 0 (Antirheumatic Agents)
RN  - 4QWG6N8QKH (Hydroxychloroquine)
RN  - 886U3H6UFF (Chloroquine)
RN  - Macular dystrophy, concentric annular
SB  - IM
MH  - Aged
MH  - Animals
MH  - Antirheumatic Agents/*adverse effects
MH  - Case-Control Studies
MH  - Cattle
MH  - Chloroquine/*adverse effects
MH  - Corneal Dystrophies, Hereditary/*chemically induced/*diagnosis/pathology
MH  - Female
MH  - Humans
MH  - Hydroxychloroquine/*adverse effects
MH  - Macular Degeneration
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Retinal Diseases/*chemically induced/*diagnosis/pathology
MH  - Tomography, Optical Coherence/*methods
MH  - Visual Acuity
EDAT- 2011/08/13 06:00
MHDA- 2012/01/10 06:00
CRDT- 2011/08/12 06:00
PHST- 2010/12/08 00:00 [received]
PHST- 2011/06/21 00:00 [accepted]
PHST- 2011/08/12 06:00 [entrez]
PHST- 2011/08/13 06:00 [pubmed]
PHST- 2012/01/10 06:00 [medline]
AID - 10.3928/15428877-20110804-02 [doi]
PST - ppublish
SO  - Ophthalmic Surg Lasers Imaging. 2011 Nov-Dec;42(6):493-7. doi: 
      10.3928/15428877-20110804-02. Epub 2011 Aug 11.