PMID- 21831696
OWN - NLM
STAT- MEDLINE
DCOM- 20120531
LR  - 20181201
IS  - 1879-0593 (Electronic)
IS  - 1368-8375 (Linking)
VI  - 48
IP  - 1
DP  - 2012 Jan
TI  - Relationship between epidermal growth factor receptor gene copy number and 
      protein expression in oral cavity squamous cell carcinoma.
PG  - 67-72
LID - 10.1016/j.oraloncology.2011.06.511 [doi]
AB  - This study was designed to explore the relationship between epidermal growth 
      factor receptor (EGFR) copy number and EGFR protein expression in oral cavity 
      squamous cell carcinoma (OSCCs) in Taiwan. A total of 160 oral cavity squamous 
      cell carcinomas were examined for EGFR protein overexpression using 
      immunohistochemistry and for copy number using a fluorescence in situ 
      hybridization (FISH) assay. Overexpression and increased gene copy numbers of 
      EGFR were found in 75 (46.88%) and 50 (31.25%) cases, respectively. The 
      concordance rate for EGFR gene amplification and protein overexpression was 100%. 
      EGFR overexpression was associated with a poor prognosis both in terms of 
      disease-free survival (DFS) and overall survival (OS). On the other hand, the 
      association between an increase in EGFR gene copies and DFS or OS was 
      insignificant. This was despite the observed significant associations between 
      gene copy number and tumor stage, depth of tumor invasion, lymph node metastasis, 
      bone invasion and perineural invasion. EGFR protein overexpression is closely 
      related to EGFR copy number. Standard methodological and interpretation criteria 
      need to be established that allows EGFR copy number combined with EGFR protein 
      expression to be determined in a manner that allows individualized EGFR targeted 
      therapy in OSCC patients.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Huang, Shiang-Fu
AU  - Huang SF
AD  - Department of Otolaryngology, Head and Neck Surgery, Chang Gung Memorial 
      Hospital, Tao-Yuan, Taiwan.
FAU - Cheng, Sou-De
AU  - Cheng SD
FAU - Chien, Huei-Tzu
AU  - Chien HT
FAU - Liao, Chun-Ta
AU  - Liao CT
FAU - Chen, I-How
AU  - Chen IH
FAU - Wang, Hung-Ming
AU  - Wang HM
FAU - Chuang, Wen-Yu
AU  - Chuang WY
FAU - Wang, Chun-Yi
AU  - Wang CY
FAU - Hsieh, Ling-Ling
AU  - Hsieh LL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110809
PL  - England
TA  - Oral Oncol
JT  - Oral oncology
JID - 9709118
RN  - 0 (Biomarkers, Tumor)
RN  - EC 2.7.10.1 (ErbB Receptors)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers, Tumor/genetics/*metabolism
MH  - Carcinoma, Squamous Cell/genetics/*metabolism/mortality
MH  - ErbB Receptors/genetics/*metabolism
MH  - Gene Amplification
MH  - Gene Dosage
MH  - *Genes, erbB-1
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Middle Aged
MH  - Mouth Neoplasms/genetics/*metabolism/mortality
MH  - Prognosis
MH  - Risk Factors
MH  - Taiwan
EDAT- 2011/08/13 06:00
MHDA- 2012/06/01 06:00
CRDT- 2011/08/12 06:00
PHST- 2011/04/12 00:00 [received]
PHST- 2011/06/21 00:00 [revised]
PHST- 2011/06/26 00:00 [accepted]
PHST- 2011/08/12 06:00 [entrez]
PHST- 2011/08/13 06:00 [pubmed]
PHST- 2012/06/01 06:00 [medline]
AID - S1368-8375(11)00750-0 [pii]
AID - 10.1016/j.oraloncology.2011.06.511 [doi]
PST - ppublish
SO  - Oral Oncol. 2012 Jan;48(1):67-72. doi: 10.1016/j.oraloncology.2011.06.511. Epub 
      2011 Aug 9.