PMID- 21832096
OWN - NLM
STAT- MEDLINE
DCOM- 20120123
LR  - 20211020
IS  - 1556-679X (Electronic)
IS  - 1556-6811 (Print)
IS  - 1556-679X (Linking)
VI  - 18
IP  - 10
DP  - 2011 Oct
TI  - Effect of the modified live porcine reproductive and respiratory syndrome virus 
      (PRRSV) vaccine on European and North American PRRSV shedding in semen from 
      infected boars.
PG  - 1600-7
LID - 10.1128/CVI.05213-11 [doi]
AB  - The objective of the present study was to compare the effects of the modified 
      live porcine reproductive and respiratory syndrome virus (PRRSV) vaccine 
      (Ingelvac PRRS MLV; Boehringer Ingelheim Animal Health, St. Joseph, MO) on 
      European and North American PRRSV shedding in the semen of experimentally 
      infected boars. The boars were randomly divided into six groups. Vaccinated boars 
      shed the North American PRRSV at the rate of 10(0.1) to 10(1.0) viral genome 
      copies per ml and 3.63 to 10(1.1) 50% tissue culture infective doses 
      (TCID(50))/ml, respectively, in semen, whereas nonvaccinated boars shed the North 
      American PRRSV at the rate of 10(0.2) to 10(4.7) viral genome copies per ml and 
      1.14 to 10(3.07) TCID(50)/ml, respectively, in semen. Vaccinated boars shed the 
      European PRRSV at the rate of 10(0.1) to 10(4.57) viral genome copies per ml and 
      1.66 to 10(3.10) TCID(50)/ml, respectively, in semen, whereas nonvaccinated boars 
      shed the European PRRSV at the rate of 10(0.3) to 10(5.14) viral genome copies 
      per ml and 1.69 to 10(3.17) TCID(50)/ml, respectively, in semen. The number of 
      genomic copies of the European PRRSV in semen samples was not significantly 
      different between vaccinated and nonvaccinated challenged European PRRSV boars. 
      The present study demonstrated that boar vaccination using commercial modified 
      live PRRSV vaccine was able to decrease subsequent shedding of North American 
      PRRSV in semen after challenge but was unable to decrease shedding of European 
      PRRSV in semen after challenge.
FAU - Han, Kiwon
AU  - Han K
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, 599 Gwanak-ro, Gwanak-gu, Seoul 151-742, Republic of Korea.
FAU - Seo, Hwi Won
AU  - Seo HW
FAU - Shin, Jeoung Hwa
AU  - Shin JH
FAU - Oh, Yeonsu
AU  - Oh Y
FAU - Kang, Ikjae
AU  - Kang I
FAU - Park, Changhoon
AU  - Park C
FAU - Chae, Chanhee
AU  - Chae C
LA  - eng
SI  - GENBANK/JN315685
SI  - GENBANK/JN315686
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110810
PL  - United States
TA  - Clin Vaccine Immunol
JT  - Clinical and vaccine immunology : CVI
JID - 101252125
RN  - 0 (RNA, Viral)
RN  - 0 (Vaccines, Attenuated)
RN  - 0 (Viral Vaccines)
SB  - IM
MH  - Animals
MH  - Molecular Sequence Data
MH  - Porcine Reproductive and Respiratory Syndrome/*prevention & control/virology
MH  - Porcine respiratory and reproductive syndrome virus/*immunology/isolation & 
      purification
MH  - RNA, Viral/genetics
MH  - Semen/immunology/*virology
MH  - Sequence Analysis, DNA
MH  - Swine
MH  - Vaccines, Attenuated/administration & dosage/immunology
MH  - Viral Load
MH  - Viral Vaccines/administration & dosage/*immunology
MH  - Virus Shedding/*immunology
PMC - PMC3187033
EDAT- 2011/08/13 06:00
MHDA- 2012/01/24 06:00
PMCR- 2012/04/01
CRDT- 2011/08/12 06:00
PHST- 2011/08/12 06:00 [entrez]
PHST- 2011/08/13 06:00 [pubmed]
PHST- 2012/01/24 06:00 [medline]
PHST- 2012/04/01 00:00 [pmc-release]
AID - CVI.05213-11 [pii]
AID - 5213-11 [pii]
AID - 10.1128/CVI.05213-11 [doi]
PST - ppublish
SO  - Clin Vaccine Immunol. 2011 Oct;18(10):1600-7. doi: 10.1128/CVI.05213-11. Epub 
      2011 Aug 10.