PMID- 21833377
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120824
LR  - 20220309
IS  - 2156-7085 (Electronic)
IS  - 2156-7085 (Linking)
VI  - 2
IP  - 8
DP  - 2011 Aug 1
TI  - Automated 3-D method for the correction of axial artifacts in spectral-domain 
      optical coherence tomography images.
PG  - 2403-16
LID - 10.1364/BOE.2.002403 [doi]
AB  - The 3-D spectral-domain optical coherence tomography (SD-OCT) images of the 
      retina often do not reflect the true shape of the retina and are distorted 
      differently along the x and y axes. In this paper, we propose a novel technique 
      that uses thin-plate splines in two stages to estimate and correct the distinct 
      axial artifacts in SD-OCT images. The method was quantitatively validated using 
      nine pairs of OCT scans obtained with orthogonal fast-scanning axes, where a 
      segmented surface was compared after both datasets had been corrected. The mean 
      unsigned difference computed between the locations of this artifact-corrected 
      surface after the single-spline and dual-spline correction was 23.36 +/- 4.04 mum 
      and 5.94 +/- 1.09 mum, respectively, and showed a significant difference (p < 0.001 
      from two-tailed paired t-test). The method was also validated using depth maps 
      constructed from stereo fundus photographs of the optic nerve head, which were 
      compared to the flattened top surface from the OCT datasets. Significant 
      differences (p < 0.001) were noted between the artifact-corrected datasets and 
      the original datasets, where the mean unsigned differences computed over 30 
      optic-nerve-head-centered scans (in normalized units) were 0.134 +/- 0.035 and 
      0.302 +/- 0.134, respectively.
FAU - Antony, Bhavna
AU  - Antony B
FAU - Abramoff, Michael D
AU  - Abramoff MD
FAU - Tang, Li
AU  - Tang L
FAU - Ramdas, Wishal D
AU  - Ramdas WD
FAU - Vingerling, Johannes R
AU  - Vingerling JR
FAU - Jansonius, Nomdo M
AU  - Jansonius NM
FAU - Lee, Kyungmoo
AU  - Lee K
FAU - Kwon, Young H
AU  - Kwon YH
FAU - Sonka, Milan
AU  - Sonka M
FAU - Garvin, Mona K
AU  - Garvin MK
LA  - eng
GR  - R01 EY019112-02/EY/NEI NIH HHS/United States
GR  - R01 EB004640/EB/NIBIB NIH HHS/United States
GR  - R01 EY019112-01A2/EY/NEI NIH HHS/United States
GR  - R01 EY018853/EY/NEI NIH HHS/United States
GR  - R01 EY017066/EY/NEI NIH HHS/United States
GR  - R01 EY019112/EY/NEI NIH HHS/United States
GR  - R01 EY019112-03/EY/NEI NIH HHS/United States
PT  - Journal Article
DEP - 20110727
PL  - United States
TA  - Biomed Opt Express
JT  - Biomedical optics express
JID - 101540630
PMC - PMC3149538
OTO - NOTNLM
OT  - (100.0100) Image processing
OT  - (100.6890) Three-dimensional image processing
OT  - (110.4500) Optical coherence tomography
EDAT- 2011/08/13 06:00
MHDA- 2011/08/13 06:01
PMCR- 2011/07/27
CRDT- 2011/08/12 06:00
PHST- 2011/06/20 00:00 [received]
PHST- 2011/07/13 00:00 [revised]
PHST- 2011/07/19 00:00 [accepted]
PHST- 2011/08/12 06:00 [entrez]
PHST- 2011/08/13 06:00 [pubmed]
PHST- 2011/08/13 06:01 [medline]
PHST- 2011/07/27 00:00 [pmc-release]
AID - 149109 [pii]
AID - 10.1364/BOE.2.002403 [doi]
PST - ppublish
SO  - Biomed Opt Express. 2011 Aug 1;2(8):2403-16. doi: 10.1364/BOE.2.002403. Epub 2011 
      Jul 27.