PMID- 21834257
OWN - NLM
STAT- MEDLINE
DCOM- 20110825
LR  - 20110812
IS  - 0309-3913 (Print)
IS  - 0309-3913 (Linking)
VI  - 40
IP  - 1
DP  - 2011 Mar
TI  - Five year review of treatment outcome of directly observed therapy (DOT) for 
      re-treatment pulmonary tuberculosis patients in UCH, Ibadan, Nigeria.
PG  - 15-21
AB  - Tuberculosis (TB) is a major health problem in Nigeria. The country is currently 
      fourth among the 22 high-burden countries (HBCs) of the world, with an incident 
      of all new cases of 311/100,000 population per year out of which 137/100,000 
      population are smear positive and prevalence of 616/100,000 population. To 
      highlight the burden of re-treatment smear positive pulmonary TB with and without 
      HIV infection and determine how directly observed therapy (DOT) using the 
      retreatment regimen has affected the treatment outcome in the management of these 
      patients. A five-year retrospective study from April 2003 to March 2008 to 
      evaluate the treatment outcome data of re-treatment pulmonary TB who were also 
      screened and confirmed for HIV at the outpatient clinic of the University College 
      Hospital Ibadan, Nigeria. The effect of HIV status and treatment outcome was 
      assessed so also the prevalence of HIV among recurrent FPTB patients. The total 
      number of cases assessed was 127. Majority of the patients were between the ages 
      of 20 to 49 (73.2%). Forty-two of the PTB patients were HIV positive (33.1%). The 
      treatment outcome was as follows: Cured 81 (63.8); Treatment completed 13(10.2%); 
      Died 22 (17.3%); Defaulted four (3.1%) and transferred out seven (5.5%) More 
      patients were cured and had treatment completion among the HIV negative patients 
      compared with HIV positive patients (p < 0.0001) The mortality was higher in 
      those with HIV positive than negative patients (p < 0.0001). Re-treatment 
      pulmonary TB is frequent at this referral centre. A contribution to re-treatment 
      prevention entails more rigorous management of new TB cases, particularly at 
      lower levels of care. This effort will reduce the emergence of multi-drug 
      resistant (MDR-TB) tuberculosis.
FAU - Ige, O M
AU  - Ige OM
AD  - Pulmonary Unit (Adult), Department of Medicine, University College Hospital, 
      Ibadan, Nigeria. olusojiige@yahoo.com
FAU - Akindele, M O
AU  - Akindele MO
LA  - eng
PT  - Journal Article
PL  - Nigeria
TA  - Afr J Med Med Sci
JT  - African journal of medicine and medical sciences
JID - 7801013
RN  - 0 (Antitubercular Agents)
SB  - IM
MH  - AIDS-Related Opportunistic Infections/diagnosis/*drug therapy
MH  - Adolescent
MH  - Adult
MH  - Age Distribution
MH  - Aged
MH  - Antitubercular Agents/*therapeutic use
MH  - Comorbidity
MH  - *Directly Observed Therapy
MH  - Female
MH  - Follow-Up Studies
MH  - HIV Seropositivity/complications
MH  - Hospitals, Teaching
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nigeria/epidemiology
MH  - Prevalence
MH  - Recurrence
MH  - Retrospective Studies
MH  - Sex Distribution
MH  - *Treatment Outcome
MH  - Tuberculosis, Pulmonary/complications/*drug therapy/epidemiology
MH  - Young Adult
EDAT- 2011/08/13 06:00
MHDA- 2011/08/27 06:00
CRDT- 2011/08/13 06:00
PHST- 2011/08/13 06:00 [entrez]
PHST- 2011/08/13 06:00 [pubmed]
PHST- 2011/08/27 06:00 [medline]
PST - ppublish
SO  - Afr J Med Med Sci. 2011 Mar;40(1):15-21.