PMID- 21835469
OWN - NLM
STAT- MEDLINE
DCOM- 20120607
LR  - 20220408
IS  - 1873-6750 (Electronic)
IS  - 0160-4120 (Linking)
VI  - 40
DP  - 2012 Apr
TI  - Associations of persistent organic pollutants with abdominal obesity in the 
      elderly: The Prospective Investigation of the Vasculature in Uppsala Seniors 
      (PIVUS) study.
PG  - 170-178
LID - S0160-4120(11)00208-X [pii]
LID - 10.1016/j.envint.2011.07.010 [doi]
AB  - OBJECTIVES: In animal experiments, persistent organic pollutants (POPs) have 
      induced visceral obesity. To address this possibility in humans, we evaluated 
      associations between POPs and abdominal obesity both cross-sectionally and 
      prospectively. METHODS: Twenty-one plasma POPs (16 polychlorinated biphenyl (PCB) 
      congeners, 3 organochlorine (OC) pesticides, 1 brominated diphenyl ether (BDE), 
      and 1 dioxin) were measured at baseline in 970 participants aged 70 years of the 
      Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS), with 
      prospective analyses in 511 participants re-examined after 5 years. Abdominal 
      obesity was defined by an increased waist circumference. RESULTS: In the 
      cross-sectional analyses, concentrations of the less chlorinated PCBs, OC 
      pesticides such as p,p'-DDE and dioxin had adjusted odds ratios of 2 to 3 for 
      abdominal obesity. Many relations had inverted U-shapes rather than being linear, 
      particularly in women. In contrast, concentrations of highly chlorinated PCBs 
      were strongly inversely associated with abdominal obesity. In a single model 
      including summary measures of the less chlorinated PCBs, highly chlorinated PCBs, 
      and OC pesticides, both the positive associations and inverse associations 
      strengthened. Similar but somewhat weaker associations were seen between POPs and 
      risk of development of abdominal obesity in the prospective analyses. CONCLUSION: 
      Using both a cross-sectional and a prospective design, low-dose exposure to less 
      chlorinated PCBs, p,p'-DDE, and dioxin, were associated with existence or 
      development of abdominal obesity, while highly chlorinated PCBs had an opposite 
      association in an elderly population, despite the previous observation of higher 
      incident diabetes associated with these same PCBs.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Lee, Duk-Hee
AU  - Lee DH
AD  - Department of Preventative Medicine, School of Medicine, Kyungpook National 
      University, Daegu, Republic of Korea. Electronic address: lee_dh@knu.ac.kr.
FAU - Lind, Lars
AU  - Lind L
AD  - Acute and Internal Medicine, Department of Medicine, Uppsala University Hospital, 
      Uppsala, Sweden.
FAU - Jacobs, David R Jr
AU  - Jacobs DR Jr
AD  - Division of Epidemiology and Community Health, School of Public Health, 
      University of Minnesota, Minneapolis, MN, United States; Department of Nutrition, 
      School of Medicine, University of Oslo, Oslo, Norway.
FAU - Salihovic, Samira
AU  - Salihovic S
AD  - MTM Research Center, School of Science and Technology, Orebro University, Orebro, 
      Sweden.
FAU - van Bavel, Bert
AU  - van Bavel B
AD  - MTM Research Center, School of Science and Technology, Orebro University, Orebro, 
      Sweden.
FAU - Lind, P Monica
AU  - Lind PM
AD  - Occupational and Environmental Medicine, Uppsala University, Uppsala, Sweden.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110810
PL  - Netherlands
TA  - Environ Int
JT  - Environment international
JID - 7807270
RN  - 0 (Dioxins)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Halogenated Diphenyl Ethers)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 0 (Pesticides)
RN  - 0 (Polychlorinated Dibenzodioxins)
RN  - 4M7FS82U08 (Dichlorodiphenyl Dichloroethylene)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Aged
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus
MH  - Dichlorodiphenyl Dichloroethylene/blood
MH  - Dioxins/blood
MH  - Environmental Exposure/*statistics & numerical data
MH  - Environmental Pollutants/*blood
MH  - Female
MH  - Halogenated Diphenyl Ethers/blood
MH  - Humans
MH  - Hydrocarbons, Chlorinated/blood
MH  - Male
MH  - Obesity, Abdominal/*epidemiology
MH  - Odds Ratio
MH  - Pesticides/blood
MH  - Polychlorinated Biphenyls/blood
MH  - Polychlorinated Dibenzodioxins/blood
MH  - Prospective Studies
MH  - Sweden
EDAT- 2011/08/13 06:00
MHDA- 2012/06/08 06:00
CRDT- 2011/08/13 06:00
PHST- 2011/05/08 00:00 [received]
PHST- 2011/07/15 00:00 [revised]
PHST- 2011/07/15 00:00 [accepted]
PHST- 2011/08/13 06:00 [entrez]
PHST- 2011/08/13 06:00 [pubmed]
PHST- 2012/06/08 06:00 [medline]
AID - S0160-4120(11)00208-X [pii]
AID - 10.1016/j.envint.2011.07.010 [doi]
PST - ppublish
SO  - Environ Int. 2012 Apr;40:170-178. doi: 10.1016/j.envint.2011.07.010. Epub 2011 
      Aug 10.