PMID- 21836340
OWN - NLM
STAT- MEDLINE
DCOM- 20120117
LR  - 20211020
IS  - 1998-3689 (Electronic)
IS  - 0301-4738 (Print)
IS  - 0301-4738 (Linking)
VI  - 59
IP  - 5
DP  - 2011 Sep-Oct
TI  - Macular hole in Behcet's disease.
PG  - 359-62
LID - 10.4103/0301-4738.83611 [doi]
AB  - OBJECTIVE: To investigate the clinical features, prevalence, role of surgical 
      intervention and the visual prognosis of macular holes (MH) in patients with 
      Behcet's disease (BD). MATERIALS AND METHODS: Retrospective study of patients 
      with BD and MH from January 1998 to November 2008. RESULTS: Out of 159 patients, 
      21 eyes of 17 patients were identified with MH. The mean age was 38.59 (range 
      23-61) years and the mean follow-up period was 5.1 years (range 13-164 months). 
      The prevalence of MH was 7%. Visual acuity (VA) at the time of presentation 
      ranged from 20/70 to hand-motion. Optical coherence tomography (OCT) findings 
      revealed intraretinal cysts at the edge of the MH. The mean size of MH was 983.6 
      um; 52% had elevated edges, 43% had flat edges and only one eye (5%) was closed 
      postoperatively. Fluorescein angiography (FA) was consistent with macular 
      ischemia in 76% of the cases. Human leukocyte antigen (HLA) B51 association was 
      found in 14 of the 15 patients investigated. Six patients (out of 17) underwent 
      pars plana vitrectomy. The final VA on their last follow-up ranged from 20/70 to 
      2/200. Surgical intervention for MH did not result in any visual improvement as 
      compared to non-operated eyes. One patient lost vision completely due to elevated 
      intraocular pressure post vitrectomy and silicon oil tamponade. CONCLUSIONS: MH 
      in patients with BD may lead to significant visual disability. Surgical 
      intervention does not seem to have any potential beneficial effect on the VA, 
      probably due to significant macular ischemia and sequelae from the ocular 
      inflammation.
FAU - Al-Dhibi, Hassan
AU  - Al-Dhibi H
AD  - Uveitis Division, College of Medicine, King Saud University, Riyadh, Saudi 
      Arabia. hdhibi@yahoo.com
FAU - Abouammoh, Marwan
AU  - Abouammoh M
FAU - Al-Harthi, Essam
AU  - Al-Harthi E
FAU - Al-Gaeed, Abdulrahman
AU  - Al-Gaeed A
FAU - Larsson, Jorgen
AU  - Larsson J
FAU - Abboud, Emad
AU  - Abboud E
FAU - Chaudhry, Imtiaz
AU  - Chaudhry I
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - India
TA  - Indian J Ophthalmol
JT  - Indian journal of ophthalmology
JID - 0405376
SB  - IM
MH  - Adult
MH  - Behcet Syndrome/*complications/diagnosis
MH  - Diagnosis, Differential
MH  - Female
MH  - Fluorescein Angiography
MH  - Follow-Up Studies
MH  - Fundus Oculi
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Retina/*pathology/physiopathology
MH  - Retinal Perforations/diagnosis/*etiology/surgery
MH  - Retrospective Studies
MH  - Tomography, Optical Coherence
MH  - Treatment Outcome
MH  - Visual Acuity
MH  - Vitrectomy/methods
MH  - Young Adult
PMC - PMC3159316
COIS- Conflict of Interest: None declared.
EDAT- 2011/08/13 06:00
MHDA- 2012/01/18 06:00
PMCR- 2011/09/01
CRDT- 2011/08/13 06:00
PHST- 2011/08/13 06:00 [entrez]
PHST- 2011/08/13 06:00 [pubmed]
PHST- 2012/01/18 06:00 [medline]
PHST- 2011/09/01 00:00 [pmc-release]
AID - IndianJOphthalmol_2011_59_5_359_83611 [pii]
AID - IJO-59-359 [pii]
AID - 10.4103/0301-4738.83611 [doi]
PST - ppublish
SO  - Indian J Ophthalmol. 2011 Sep-Oct;59(5):359-62. doi: 10.4103/0301-4738.83611.