PMID- 21836476
OWN - NLM
STAT- MEDLINE
DCOM- 20111007
LR  - 20151119
IS  - 1532-0979 (Electronic)
IS  - 0147-5185 (Linking)
VI  - 35
IP  - 9
DP  - 2011 Sep
TI  - Melanocytic nevi with an atypical epithelioid cell component: clinical, 
      histopathologic, and fluorescence in situ hybridization findings.
PG  - 1405-12
LID - 10.1097/PAS.0b013e31822678d2 [doi]
AB  - Combined melanocytic nevi can contain a phenotypically distinct population of 
      large atypical epithelioid cells in a background of smaller banal-appearing 
      melanocytes. On the basis of the pattern of proliferation and degree of 
      pigmentation, nevi with this pattern have been referred to as nevi with an 
      atypical epithelioid cell component (N-AECC). When N-AECC display sheet-like or 
      an expansile nodular growth pattern, notable cytologic atypia, and any level of 
      mitotic activity, they can be difficult to distinguish from melanoma. The 
      clinical history and appearance of these lesions may similarly raise concern for 
      melanoma. In view of this diagnostic problem, we present 28 cases of N-AECC from 
      our dermatopathology consultation and in-house practice. All 28 cases were found 
      to be negative on the basis of fluorescence in situ hybridization (FISH) for 
      imbalanced chromosomal aberrations commonly found in melanoma. The clinical 
      outcomes showed a benign clinical course for all cases for which the outcome 
      information was available. FISH analysis also revealed that, in 4 of 28 cases 
      (14%), the AECC of the lesion demonstrated polyploidy localized to the large 
      epithelioid cell component. This is likely more common among cases of N-AECC that 
      have an atypical spitzoid epithelioid cell component, particularly those with 
      obvious senescent nuclear changes. Care must be taken to avoid the pitfall of 
      misinterpreting these FISH findings as changes consistent with melanoma. The use 
      of ancillary testing methods including FISH may be beneficial in improving the 
      diagnostic accuracy involved in making the distinction of N-AECC from melanoma. 
      Further, we report a novel finding of polyploidy seen in certain cases of benign 
      N-AECC.
FAU - Pouryazdanparast, Pedram
AU  - Pouryazdanparast P
AD  - Department of Dermatology, Robert H. Lurie Cancer Center, Feinberg School of 
      Medicine, Northwestern University, 676 N. St. Clair Street, Chicago, IL 60611, 
      USA.
FAU - Haghighat, Zahra
AU  - Haghighat Z
FAU - Beilfuss, Beth Ann
AU  - Beilfuss BA
FAU - Guitart, Joan
AU  - Guitart J
FAU - Gerami, Pedram
AU  - Gerami P
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Surg Pathol
JT  - The American journal of surgical pathology
JID - 7707904
RN  - 0 (Biomarkers, Tumor)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Biomarkers, Tumor/analysis/genetics
MH  - Biopsy
MH  - Cell Proliferation
MH  - Chicago
MH  - Child
MH  - Epithelioid Cells/chemistry/*pathology
MH  - Female
MH  - Gene Expression Regulation, Neoplastic
MH  - Genotype
MH  - Humans
MH  - Immunohistochemistry
MH  - *In Situ Hybridization, Fluorescence
MH  - Male
MH  - Middle Aged
MH  - Mutation
MH  - Nevus, Pigmented/chemistry/*diagnosis/genetics/pathology
MH  - Phenotype
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Skin Neoplasms/chemistry/*diagnosis/genetics/pathology
MH  - Young Adult
EDAT- 2011/08/13 06:00
MHDA- 2011/10/08 06:00
CRDT- 2011/08/13 06:00
PHST- 2011/08/13 06:00 [entrez]
PHST- 2011/08/13 06:00 [pubmed]
PHST- 2011/10/08 06:00 [medline]
AID - 10.1097/PAS.0b013e31822678d2 [doi]
PST - ppublish
SO  - Am J Surg Pathol. 2011 Sep;35(9):1405-12. doi: 10.1097/PAS.0b013e31822678d2.