PMID- 21837784
OWN - NLM
STAT- MEDLINE
DCOM- 20120206
LR  - 20221207
IS  - 1096-9071 (Electronic)
IS  - 0146-6615 (Print)
IS  - 0146-6615 (Linking)
VI  - 83
IP  - 10
DP  - 2011 Oct
TI  - Prevalence of human papillomavirus genotypes and associated cervical squamous 
      intraepithelial lesions in HIV-infected women in Botswana.
PG  - 1689-95
LID - 10.1002/jmv.22178 [doi]
AB  - Human papillomaviruses (HPV) constitute one of the most prevalent sexually 
      transmitted infections and are the etiological agents for invasive cervical 
      cancer, the predominant cancer among women in Botswana. However, the prevalence 
      of HPV genotypes in Botswana has yet to be reported. One hundred thirty-nine 
      endocervical swabs were taken at baseline from HIV-1 infected, HSV-2 seropositive 
      women enrolled in a longitudinal cohort study designed to assess the influence of 
      herpes simplex virus-2 (HSV-2) infection on genital tract shedding of HIV-1. 
      Extracted DNA was evaluated for the presence of low-risk and high-risk HPV using 
      the Roche Linear Array. Genotyping identified HPV in 95 of 139 women of which 
      61/95 were infected with high-risk HPV and 56/95 with low-risk HPV. The median 
      number of genotypes was 2 (IQR: 1-4). The most prevalent HPV genotype in 
      HIV-infected women was HPV 58. Abnormal cervical cytology was detected in 87/127 
      women and was associated with contemporaneous HPV infection (RR = 1.43, 95% CI: 
      1.05-1.93; P = 0.02). HPV prevalence was high among HIV-infected women with 
      infection by multiple genotypes being widespread. The associations attributed to 
      specific oncogenic HPV subtypes and cervical squamous intraepithelial lesions 
      presented here provide critical information to inform future vaccine policy 
      within Botswana.
CI  - Copyright (c) 2011 Wiley-Liss, Inc.
FAU - Macleod, Iain J
AU  - Macleod IJ
AD  - Harvard School of Public Health AIDS Initiative, Department of Immunology and 
      Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, USA.
FAU - O'Donnell, Belinda
AU  - O'Donnell B
FAU - Moyo, Sikhulile
AU  - Moyo S
FAU - Lockman, Shahin
AU  - Lockman S
FAU - Shapiro, Roger L
AU  - Shapiro RL
FAU - Kayembe, Mukendi
AU  - Kayembe M
FAU - van Widenfelt, Erik
AU  - van Widenfelt E
FAU - Makhema, Joseph
AU  - Makhema J
FAU - Essex, M
AU  - Essex M
FAU - Wester, Carolyn
AU  - Wester C
LA  - eng
GR  - K23 HD049292/HD/NICHD NIH HHS/United States
GR  - K23 HD049292-05/HD/NICHD NIH HHS/United States
GR  - P30 AI060354/AI/NIAID NIH HHS/United States
GR  - K23HD049292/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - J Med Virol
JT  - Journal of medical virology
JID - 7705876
RN  - 0 (Capsid Proteins)
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Adult
MH  - Alphapapillomavirus/classification/*genetics
MH  - Botswana/epidemiology
MH  - Capsid Proteins/genetics/immunology
MH  - Cohort Studies
MH  - DNA, Viral/genetics
MH  - Female
MH  - Genotype
MH  - HIV Infections/*complications
MH  - Herpes Genitalis/complications
MH  - Herpesvirus 2, Human/immunology
MH  - Humans
MH  - Longitudinal Studies
MH  - Papillomavirus Infections/*complications/*virology
MH  - Uterine Cervical Dysplasia/epidemiology/*virology
PMC - PMC3156037
MID - NIHMS307390
EDAT- 2011/08/13 06:00
MHDA- 2012/02/07 06:00
PMCR- 2012/10/01
CRDT- 2011/08/13 06:00
PHST- 2011/08/13 06:00 [entrez]
PHST- 2011/08/13 06:00 [pubmed]
PHST- 2012/02/07 06:00 [medline]
PHST- 2012/10/01 00:00 [pmc-release]
AID - 10.1002/jmv.22178 [doi]
PST - ppublish
SO  - J Med Virol. 2011 Oct;83(10):1689-95. doi: 10.1002/jmv.22178.