PMID- 21838089
OWN - NLM
STAT- MEDLINE
DCOM- 20110927
LR  - 20131121
IS  - 0011-4162 (Print)
IS  - 0011-4162 (Linking)
VI  - 87
IP  - 6
DP  - 2011 Jun
TI  - Comparison of micronized tretinoin gel 0.05% and tretinoin gel microsphere 0.1% 
      in young adolescents with acne: a post hoc analysis of efficacy and tolerability 
      data.
PG  - 305-10
AB  - Acne vulgaris is common in young adolescents. Retinoids are widely used but may 
      be associated with poor tolerability. This post hoc analysis of 483 participants 
      aged 10 to 14 years with mild to moderate acne compared efficacy and tolerability 
      of once-daily treatment with micronized tretinoin gel 0.05%, tretinoin gel 
      microsphere 0.1%, and vehicle over 12 weeks. In study 1, inflammatory and 
      noninflammatory lesion reduction and treatment success was comparable between 
      tretinoin gel 0.05% and tretinoin gel microsphere 0.1%. Inflammatory (46.3%) and 
      noninflammatory (45.7%) lesion reductions with tretinoin gel 0.05% were 
      significantly greater than vehicle (37.1% and 27.9%, respectively) (both P<.001). 
      In study 2, inflammatory and noninflammatory lesion reductions and treatment 
      success with tretinoin gel 0.05% (30.6%, 39.1%, and 19%, respectively) were 
      significantly greater than vehicle (10.9%, 16.9% [both P<.001], and 4% [P=.008], 
      respectively). Tretinoin gel 0.05% was significantly better tolerated than 
      tretinoin gel microsphere 0.1% (P<.001); the majority of adverse events (AEs) 
      were mild, occurring in the first 2 weeks. Fourteen percent of participants 
      reported dry skin, 8% skin burning sensation, 5% erythema, and 5% dermatitis 
      exfoliative with tretinoin gel 0.05% compared with 32%, 11%, 23%, and 23%, 
      respectively, with tretinoin gel microsphere 0.1% (all P<.001, except skin 
      burning sensation). In this secondary analysis of acne in young adolescents aged 
      10 to 14 years, micronized tretinoin gel 0.05% provided a comparable lesion 
      reduction and treatment success versus tretinoin gel microsphere 0.1%, with a 
      better cutaneous tolerability profile.
FAU - Lucky, Anne W
AU  - Lucky AW
AD  - Dermatology Associates of Cincinnati, Ohio, USA. annelucky@fuse.net
FAU - Sugarman, Jeffrey
AU  - Sugarman J
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cutis
JT  - Cutis
JID - 0006440
RN  - 0 (Gels)
RN  - 0 (Keratolytic Agents)
RN  - 5688UTC01R (Tretinoin)
SB  - IM
MH  - Acne Vulgaris/*drug therapy
MH  - Adolescent
MH  - Child
MH  - Double-Blind Method
MH  - Female
MH  - Gels
MH  - Humans
MH  - Keratolytic Agents/adverse effects/*therapeutic use
MH  - Male
MH  - Microspheres
MH  - Treatment Outcome
MH  - Tretinoin/adverse effects/*therapeutic use
EDAT- 2011/08/16 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/08/16 06:00
PHST- 2011/08/16 06:00 [entrez]
PHST- 2011/08/16 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
PST - ppublish
SO  - Cutis. 2011 Jun;87(6):305-10.