PMID- 21838623
OWN - NLM
STAT- MEDLINE
DCOM- 20111024
LR  - 20110822
IS  - 1532-4303 (Electronic)
IS  - 0277-0903 (Linking)
VI  - 48
IP  - 7
DP  - 2011 Sep
TI  - sICAM-1 and TNF-alpha in asthma and rhinitis: relationship with the presence of 
      atopy.
PG  - 660-6
LID - 10.3109/02770903.2011.604886 [doi]
AB  - BACKGROUND: A genetically determined overproduction of specific immunoglobulin E 
      (IgE) underlies many diseases like asthma or allergic rhinitis. IgE as well as 
      tumor necrosis factor-alpha (TNF-alpha), and intercellular adhesion molecule-1 (ICAM-1) 
      play a critical role in the induction and maintenance of inflammation. While the 
      correlation between IgE and atopy is inseparable, little is known about the 
      correlation of atopy with markers of inflammation. OBJECTIVE: We investigated the 
      relationship between the serum concentrations of TNF-alpha, soluble ICAM-1 (sICAM-1), 
      and the presence of atopy in patients with persistent rhinitis or asthma. 
      METHODS: Serum concentrations of sICAM-1, TNF-alpha, and total IgE were investigated 
      in 64 adults with persistent allergic rhinitis, 17 subjects with nonatopic 
      rhinitis, 90 patients with asthma, and 21 healthy individuals. Atopy was 
      diagnosed on the basis of positive family history, skin prick tests, and serum 
      IgE concentration. RESULTS: Total IgE concentration was significantly higher in 
      patients with atopic rhinitis or asthma when compared with nonatopic patients and 
      healthy individuals and was the highest in patients suffering from severe atopic 
      asthma who were not treated with systemic glucocorticosteroids. Although there 
      were marked alterations in IgE in atopic and nonatopic patients, there were no 
      significant differences between atopic and corresponding groups of nonatopic 
      rhinitic and asthmatic patients in sICAM-1 and TNF-alpha concentrations. (sICAM-1 in 
      rhinitis: atopic vs. nonatopic patients: 224.02 and 221.08 ng/ml, respectively, p 
      > .05; in mild/moderate asthma: atopic vs. nonatopic: 306.22 and 326.39 ng/ml, 
      respectively, p > .05; severe asthma without oral corticosteroids therapy: atopic 
      vs. nonatopic: 418.03 and 468.09 ng/ml, respectively, p > .05; and severe asthma 
      with oral corticosteroids therapy: atopic vs. nonatopic: 320.66 and 308.09 ng/ml, 
      respectively, p > .05). CONCLUSIONS: Concentrations of sICAM-1 and TNF-alpha are 
      significantly higher in patients with asthma compared with those observed in 
      patients with rhinitis, but they are independent of the presence of atopy.
FAU - Ciebiada, Maciej
AU  - Ciebiada M
AD  - Department of Pneumonology and Allergy, Medical University of Lodz, Lodz, Poland. 
      maciej_ciebiada@op.pl
FAU - Gorska-Ciebiada, Malgorzata
AU  - Gorska-Ciebiada M
FAU - Gorski, Pawel
AU  - Gorski P
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110815
PL  - England
TA  - J Asthma
JT  - The Journal of asthma : official journal of the Association for the Care of 
      Asthma
JID - 8106454
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 126547-89-5 (Intercellular Adhesion Molecule-1)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Asthma/blood/*immunology
MH  - Case-Control Studies
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Intercellular Adhesion Molecule-1/*blood
MH  - Male
MH  - Middle Aged
MH  - Rhinitis, Allergic, Perennial/blood/*immunology
MH  - Tumor Necrosis Factor-alpha/*blood
EDAT- 2011/08/16 06:00
MHDA- 2011/10/25 06:00
CRDT- 2011/08/16 06:00
PHST- 2011/08/16 06:00 [entrez]
PHST- 2011/08/16 06:00 [pubmed]
PHST- 2011/10/25 06:00 [medline]
AID - 10.3109/02770903.2011.604886 [doi]
PST - ppublish
SO  - J Asthma. 2011 Sep;48(7):660-6. doi: 10.3109/02770903.2011.604886. Epub 2011 Aug 
      15.