PMID- 21839129
OWN - NLM
STAT- MEDLINE
DCOM- 20120112
LR  - 20161125
IS  - 1873-5169 (Electronic)
IS  - 0196-9781 (Linking)
VI  - 32
IP  - 9
DP  - 2011 Sep
TI  - Central administration of neuronostatin induces antinociception in mice.
PG  - 1893-901
LID - 10.1016/j.peptides.2011.07.010 [doi]
AB  - Neuronostatin, a recently discovered endogenous bioactive peptide, was encoded by 
      pro-mRNA of somatostatin that contributes to modulation of nociception. However, 
      nociceptive effect of neuronostatin is still not fully known. The aim of this 
      study was to evaluate effect of neuronostatin on nociception and elucidate its 
      possible mechanism of action. Intracerebroventricular (i.c.v.) administration of 
      neuronostatin (0.3, 3, 6, 12nmol/mouse) produced a dose- and time-related 
      antinociceptive effect in the tail immersion assay in mice, an acute pain model. 
      The antinociceptive effect of neuronostatin was significantly antagonized by 
      naloxone, and was strongly inhibited by co-injection with beta-funaltrexamine or 
      nor-binaltorphimine, but not by naltrindole. Also, melanocortin 3/4 receptor 
      antagonist, SHU9119, completely blocked the effect of neuronostatin. These data 
      indicated the involvement of both mu- and kappa-opioid receptors and central 
      melanocortin system in the analgesic response induced by neuronostatin. In 
      addition, neuronostatin (6nmol, i.c.v.) increased c-Fos protein expression in the 
      periaqueductal gray (PAG) and the nucleus raphe magnus (NRM) that have a pivotal 
      role in regulating descending pain pathways. Taken together, this study is the 
      first to reveal that neuronostatin produces antinociceptive effect via opioid and 
      central melanocortin systems, which is associated with an increase in neuronal 
      activity the PAG and NRM.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Yang, Ai-min
AU  - Yang AM
AD  - Institute of Biochemistry and Molecular Biology, School of Life Sciences, Lanzhou 
      University, 222 Tian Shui South Road, Lanzhou, 730000, PR China.
FAU - Ge, Wan-wen
AU  - Ge WW
FAU - Lu, Song-song
AU  - Lu SS
FAU - Yang, Shao-bin
AU  - Yang SB
FAU - Su, Shu-fang
AU  - Su SF
FAU - Mi, Ze-yun
AU  - Mi ZY
FAU - Chen, Qiang
AU  - Chen Q
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110802
PL  - United States
TA  - Peptides
JT  - Peptides
JID - 8008690
RN  - 0 (Analgesics)
RN  - 0 (Mc3r protein, mouse)
RN  - 0 (Narcotic Antagonists)
RN  - 0 (Peptide Hormones)
RN  - 0 (Proto-Oncogene Proteins c-fos)
RN  - 0 (Receptor, Melanocortin, Type 3)
RN  - 0 (Receptor, Melanocortin, Type 4)
RN  - 0 (neuronostatin, mouse)
RN  - 168482-23-3 (SHU 9119)
RN  - 36B82AMQ7N (Naloxone)
RN  - 36OOQ86QM1 (norbinaltorphimine)
RN  - 5S6W795CQM (Naltrexone)
RN  - 72782-05-9 (beta-funaltrexamine)
RN  - 9002-79-3 (Melanocyte-Stimulating Hormones)
SB  - IM
MH  - Acute Pain/drug therapy
MH  - Analgesics/administration & dosage/pharmacology
MH  - Animals
MH  - Dose-Response Relationship, Drug
MH  - Immunohistochemistry
MH  - Infusions, Intraventricular
MH  - Male
MH  - Melanocyte-Stimulating Hormones/pharmacology
MH  - Mice
MH  - Models, Animal
MH  - Naloxone/pharmacology
MH  - Naltrexone/analogs & derivatives/pharmacology
MH  - Narcotic Antagonists
MH  - Nociception/*drug effects
MH  - Peptide Hormones/*administration & dosage/antagonists & inhibitors/chemical 
      synthesis/*pharmacology
MH  - Periaqueductal Gray/drug effects
MH  - Proto-Oncogene Proteins c-fos/metabolism
MH  - Receptor, Melanocortin, Type 3/antagonists & inhibitors
MH  - Receptor, Melanocortin, Type 4/antagonists & inhibitors
EDAT- 2011/08/16 06:00
MHDA- 2012/01/13 06:00
CRDT- 2011/08/16 06:00
PHST- 2011/06/03 00:00 [received]
PHST- 2011/07/11 00:00 [revised]
PHST- 2011/07/11 00:00 [accepted]
PHST- 2011/08/16 06:00 [entrez]
PHST- 2011/08/16 06:00 [pubmed]
PHST- 2012/01/13 06:00 [medline]
AID - S0196-9781(11)00285-3 [pii]
AID - 10.1016/j.peptides.2011.07.010 [doi]
PST - ppublish
SO  - Peptides. 2011 Sep;32(9):1893-901. doi: 10.1016/j.peptides.2011.07.010. Epub 2011 
      Aug 2.