PMID- 21839273
OWN - NLM
STAT- MEDLINE
DCOM- 20120105
LR  - 20110815
IS  - 1873-2623 (Electronic)
IS  - 0041-1345 (Linking)
VI  - 43
IP  - 6
DP  - 2011 Jul-Aug
TI  - Impact of IL2 and IL2RB genetic polymorphisms in kidney transplantation.
PG  - 2383-7
LID - 10.1016/j.transproceed.2011.06.014 [doi]
AB  - Patient genetic make-up may contribute to a higher risk for acute rejection 
      episodes (AREs). Because interleukin-2 (IL2) and IL2 receptor beta (IL2RB) play key 
      roles in immune modulation, we investigated the effect of single-nucleotide 
      polymorphisms (SNPs) in the IL2 gene (rs2069762; T>G, promoter; and rs2069763; 
      G>T, exon 1, Leu38Leu) and IL2RB gene (rs228942: C>A, exon 1, Asp391Glu; and 
      rs228953: C>T, exon 8, Gly250Gly) on renal ARE risk in 61 ARE patients and 276 
      control renal allograft recipients in Korea. The genotype frequencies of the IL2 
      and IL2RB SNPs showed Hardy-Weinberg equilibrium in both ARE and control groups. 
      No significant difference in the genotype frequencies of the 2 IL2 SNPs was 
      detected between non-ARE and ARE subjects (P > .05). The occurrence of AREs was 
      significantly associated with genetic variants of the IL2RB gene (rs228942: odds 
      ratio [OR] 2.11, 95% confidence interval [CI] 1.19-3.74; P = .0096, dominant 
      model; rs228953: OR 1.58, 95% CI 1.04-2.38; P = .029, codominant model). In the 
      haplotype-based analysis, the AC haplotype of IL2RB (chi(2) = 4.738; P = .0295) 
      showed associations with ARE. Our results demonstrate that genetic variants of 
      IL2RB may be associated with the development of AREs and may help predict ARE 
      risk in kidney transplantation patients.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Park, S J
AU  - Park SJ
AD  - Organ Transplantation Center, College of Medicine, Inje University, Busan, South 
      Korea.
FAU - Yoon, Y C
AU  - Yoon YC
FAU - Kang, S W
AU  - Kang SW
FAU - Kim, T H
AU  - Kim TH
FAU - Kim, Y W
AU  - Kim YW
FAU - Joo, H
AU  - Joo H
FAU - Kim, H J
AU  - Kim HJ
FAU - Jeong, K H
AU  - Jeong KH
FAU - Lee, D Y
AU  - Lee DY
FAU - Lee, S S
AU  - Lee SS
FAU - Chung, J H
AU  - Chung JH
FAU - Kim, Y H
AU  - Kim YH
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Transplant Proc
JT  - Transplantation proceedings
JID - 0243532
RN  - 0 (IL2 protein, human)
RN  - 0 (IL2RB protein, human)
RN  - 0 (Interleukin-2)
RN  - 0 (Interleukin-2 Receptor beta Subunit)
SB  - IM
MH  - Acute Disease
MH  - Adult
MH  - Case-Control Studies
MH  - Chi-Square Distribution
MH  - Exons
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Graft Rejection/*genetics/immunology
MH  - Haplotypes
MH  - Humans
MH  - Interleukin-2/*genetics
MH  - Interleukin-2 Receptor beta Subunit/*genetics
MH  - *Kidney Transplantation/immunology
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Odds Ratio
MH  - Phenotype
MH  - *Polymorphism, Single Nucleotide
MH  - Promoter Regions, Genetic
MH  - Republic of Korea
MH  - Risk Assessment
MH  - Risk Factors
MH  - Treatment Outcome
EDAT- 2011/08/16 06:00
MHDA- 2012/01/06 06:00
CRDT- 2011/08/16 06:00
PHST- 2011/08/16 06:00 [entrez]
PHST- 2011/08/16 06:00 [pubmed]
PHST- 2012/01/06 06:00 [medline]
AID - S0041-1345(11)00822-0 [pii]
AID - 10.1016/j.transproceed.2011.06.014 [doi]
PST - ppublish
SO  - Transplant Proc. 2011 Jul-Aug;43(6):2383-7. doi: 
      10.1016/j.transproceed.2011.06.014.