PMID- 21839369
OWN - NLM
STAT- MEDLINE
DCOM- 20111213
LR  - 20231213
IS  - 1558-4488 (Electronic)
IS  - 0270-9295 (Linking)
VI  - 31
IP  - 4
DP  - 2011 Jul
TI  - Crescentic glomerulonephritis: new aspects of pathogenesis.
PG  - 361-8
LID - 10.1016/j.semnephrol.2011.06.007 [doi]
AB  - This review provides a summary of recent advances in the understanding of 
      crescentic glomerulonephritis, focusing on antineutrophil cytoplasm antibody 
      (ANCA)-associated vasculitis and anti-glomerular basement membrane (anti-GBM) 
      antibody disease. In ANCA-associated vasculitis (AAV), four main conceptual 
      advances are discussed as follows: (1) evidence for the pathogenicity of ANCA, 
      (2) molecular mimicry and the role of infection in AAV, (3) evidence for aberrant 
      T-cell responses and T-cell regulation in AAV, and (4) advances in understanding 
      of genetic predisposition to AAV. In relation to anti-GBM disease we discuss the 
      following: (1) the nature of the Goodpasture autoantigens, (2) T-cell responses 
      and regulation in anti-GBM disease, and (3) human leukocyte antigen and non-human 
      leukocyte antigen genetic associations.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Tarzi, Ruth M
AU  - Tarzi RM
AD  - Department of Medicine, Imperial College London, Hammersmith Hospital, London, 
      United Kingdom. r.tarzi@imperial.ac.uk
FAU - Cook, H Terence
AU  - Cook HT
FAU - Pusey, Charles D
AU  - Pusey CD
LA  - eng
GR  - 18235/ARC_/Arthritis Research UK/United Kingdom
GR  - 18235/VAC_/Versus Arthritis/United Kingdom
GR  - WT_/Wellcome Trust/United Kingdom
GR  - MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Semin Nephrol
JT  - Seminars in nephrology
JID - 8110298
RN  - 0 (Antibodies, Antineutrophil Cytoplasmic)
RN  - 0 (Autoantibodies)
RN  - 0 (LAMP2 protein, human)
RN  - 0 (Lysosomal-Associated Membrane Protein 2)
RN  - 0 (Lysosomal Membrane Proteins)
RN  - 0 (antiglomerular basement membrane antibody)
RN  - EC 1.11.1.7 (Peroxidase)
SB  - IM
MH  - Animals
MH  - Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/etiology/genetics
MH  - Antibodies, Antineutrophil Cytoplasmic/immunology
MH  - Autoantibodies/immunology
MH  - Glomerulonephritis/*etiology/immunology
MH  - Humans
MH  - Lymphocyte Activation
MH  - Lysosomal-Associated Membrane Protein 2
MH  - Lysosomal Membrane Proteins/immunology
MH  - Peroxidase/immunology
MH  - T-Lymphocytes/immunology
EDAT- 2011/08/16 06:00
MHDA- 2011/12/14 06:00
CRDT- 2011/08/16 06:00
PHST- 2011/08/16 06:00 [entrez]
PHST- 2011/08/16 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
AID - S0270-9295(11)00068-4 [pii]
AID - 10.1016/j.semnephrol.2011.06.007 [doi]
PST - ppublish
SO  - Semin Nephrol. 2011 Jul;31(4):361-8. doi: 10.1016/j.semnephrol.2011.06.007.